8hw2 - Revision history

OCA at 11:12, 2 August 2023

OCA — Wed, 02 Aug 2023 11:12:46 GMT

←Older revision		Revision as of 11:12, 2 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8hw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8hw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HW2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U38:Estradiol-17beta-glucuronide'>U38</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U38:Estradiol-17beta-glucuronide'>U38</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hw2 OCA], [https://pdbe.org/8hw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hw2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hw2 OCA], [https://pdbe.org/8hw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hw2 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:42, 7 June 2023

OCA — Wed, 07 Jun 2023 05:42:41 GMT

←Older revision		Revision as of 05:42, 7 June 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hw2 is ~~ON HOLD~~	+	==Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs==
-		+	<StructureSection load='8hw2' size='340' side='right'caption='[[8hw2]], [[Resolution\|resolution]] 3.65Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HW2 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U38:Estradiol-17beta-glucuronide'>U38</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hw2 OCA], [https://pdbe.org/8hw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8hw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hw2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MRP3_HUMAN MRP3_HUMAN] ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813).[UniProtKB:O88563]<ref>PMID:10359813</ref> <ref>PMID:11581266</ref> <ref>PMID:15083066</ref> <ref>PMID:35307651</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen YX]]
		+	[[Category: Wang FF]]
		+	[[Category: Wang J]]
		+	[[Category: Zhou CZ]]

OCA: Protected "8hw2" [edit=sysop:move=sysop]

OCA — Wed, 11 Jan 2023 06:15:43 GMT

Protected "8hw2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 11 January 2023

OCA: New page: '''Unreleased structure''' The entry 8hw2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Jan 2023 06:15:39 GMT

New page: '''Unreleased structure''' The entry 8hw2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8hw2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]