OCA at 11:42, 1 February 2024

OCA — Thu, 01 Feb 2024 11:42:05 GMT

←Older revision		Revision as of 11:42, 1 February 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8hwl is ~~ON HOLD~~	+	==Human Pyruvate Carboxylase==
-		+	<StructureSection load='8hwl' size='340' side='right'caption='[[8hwl]], [[Resolution\|resolution]] 5.63Å' scene=''>
-	~~Authors~~: ~~Liu~~, D.S., Su, J.Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8hwl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HWL FirstGlance]. <br>
-	~~Description~~: ~~Human~~ Pyruvate ~~Carboxylase~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 5.63Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTI:5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL'>BTI</scene></td></tr>
-	[[Category: Liu~~, D.S~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hwl OCA], [https://pdbe.org/8hwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hwl RCSB], [https://www.ebi.ac.uk/pdbsum/8hwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hwl ProSAT]</span></td></tr>
-	[[Category: Su~~, J.Y~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:[https://omim.org/entry/266150 266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Liu DS]]
		+	[[Category: Su JY]]

OCA: Protected "8hwl" [edit=sysop:move=sysop]

OCA — Wed, 11 Jan 2023 06:16:28 GMT

Protected "8hwl" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:16, 11 January 2023

OCA: New page: '''Unreleased structure''' The entry 8hwl is ON HOLD Authors: Liu, D.S., Su, J.Y. Description: Human Pyruvate Carboxylase Category: Unreleased Structures Category: Liu, D.S [[C...

OCA — Wed, 11 Jan 2023 06:16:27 GMT

New page: '''Unreleased structure''' The entry 8hwl is ON HOLD Authors: Liu, D.S., Su, J.Y. Description: Human Pyruvate Carboxylase Category: Unreleased Structures Category: Liu, D.S [[C...

New page

'''Unreleased structure'''

The entry 8hwl is ON HOLD

Authors: Liu, D.S., Su, J.Y.

Description: Human Pyruvate Carboxylase
[[Category: Unreleased Structures]]
[[Category: Liu, D.S]]
[[Category: Su, J.Y]]

8hwl - Revision history

OCA at 11:42, 1 February 2024

OCA: Protected "8hwl" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8hwl is ON HOLD Authors: Liu, D.S., Su, J.Y. Description: Human Pyruvate Carboxylase Category: Unreleased Structures Category: Liu, D.S [[C...