8ia5 - Revision history

OCA at 19:53, 29 May 2024

OCA — Wed, 29 May 2024 19:53:37 GMT

←Older revision		Revision as of 19:53, 29 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8ia5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8ia5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IA5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ia5 OCA], [https://pdbe.org/8ia5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ia5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ia5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ia5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ia5 OCA], [https://pdbe.org/8ia5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ia5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ia5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ia5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>		[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
		+
		+	==See Also==
		+	*[[MDM4\|MDM4]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:48, 22 February 2023

OCA — Wed, 22 Feb 2023 12:48:57 GMT

←Older revision		Revision as of 12:48, 22 February 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8ia5 ~~is ON HOLD~~	+	==Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX==
-		+	<StructureSection load='8ia5' size='340' side='right'caption='[[8ia5]], [[Resolution\|resolution]] 1.93Å' scene=''>
-	~~Authors~~: ~~Cheng, X~~.Y., ~~Wei~~, Q.Y., ~~Huang~~, Y., Su, Z.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ia5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IA5 FirstGlance]. <br>
-	~~Description~~: ~~Small peptide enhances the binding of nutline~~-~~3a to N~~-~~terminal~~ domain of ~~MdmX~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ia5 OCA], [https://pdbe.org/8ia5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ia5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ia5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ia5 ProSAT]</span></td></tr>
-	[[Category: ~~Su, Z.D~~]]	+	</table>
-	[[Category: Huang, Y]]	+	== Function ==
-	[[Category: ~~Cheng, X.Y~~]]	+	[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
-	[[Category: Wei~~, Q.Y~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Cheng XY]]
		+	[[Category: Huang Y]]
		+	[[Category: Su ZD]]
		+	[[Category: Wei QY]]

OCA: Protected "8ia5" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2023 09:01:47 GMT

Protected "8ia5" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:01, 15 February 2023

OCA: New page: '''Unreleased structure''' The entry 8ia5 is ON HOLD Authors: Cheng, X.Y., Wei, Q.Y., Huang, Y., Su, Z.D. Description: Small peptide enhances the binding of nutline-3a to N-terminal do...

OCA — Wed, 15 Feb 2023 09:01:45 GMT

New page: '''Unreleased structure''' The entry 8ia5 is ON HOLD Authors: Cheng, X.Y., Wei, Q.Y., Huang, Y., Su, Z.D. Description: Small peptide enhances the binding of nutline-3a to N-terminal do...

New page

'''Unreleased structure'''

The entry 8ia5 is ON HOLD

Authors: Cheng, X.Y., Wei, Q.Y., Huang, Y., Su, Z.D.

Description: Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX
[[Category: Unreleased Structures]]
[[Category: Su, Z.D]]
[[Category: Huang, Y]]
[[Category: Cheng, X.Y]]
[[Category: Wei, Q.Y]]