OCA at 07:34, 3 May 2023

OCA — Wed, 03 May 2023 07:34:18 GMT

←Older revision		Revision as of 07:34, 3 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8iah is ~~ON HOLD until Paper~~ Publication	+	==Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State I, Global map==
		+	<StructureSection load='8iah' size='340' side='right'caption='[[8iah]], [[Resolution\|resolution]] 3.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8iah]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IAH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iah OCA], [https://pdbe.org/8iah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iah RCSB], [https://www.ebi.ac.uk/pdbsum/8iah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iah ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6QA25_PIG Q6QA25_PIG]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The spectrin-based membrane skeleton is a ubiquitous membrane-associated two-dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of skeleton proteins impair the mechanical strength and functions of the membrane, leading to several different types of human diseases. Here, we report the cryo-EM structures of the native spectrin-actin junctional complex (from porcine erythrocytes), which is a specialized short F-actin acting as the central organizational unit of the membrane skeleton. While an alpha-/beta-adducin hetero-tetramer binds to the barbed end of F-actin as a flexible cap, tropomodulin and SH3BGRL2 together create an absolute cap at the pointed end. The junctional complex is strengthened by ring-like structures of dematin in the middle actin layers and by patterned periodic interactions with tropomyosin over its entire length. This work serves as a structural framework for understanding the assembly and dynamics of membrane skeleton and offers insights into mechanisms of various ubiquitous F-actin-binding factors in other F-actin systems.

-	~~Authors~~:	+	Structural basis of membrane skeleton organization in red blood cells.,Li N, Chen S, Xu K, He MT, Dong MQ, Zhang QC, Gao N Cell. 2023 Apr 4:S0092-8674(23)00278-7. doi: 10.1016/j.cell.2023.03.017. PMID:37044097<ref>PMID:37044097</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8iah" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Chen S]]
		+	[[Category: Gao N]]
		+	[[Category: Li N]]

OCA at 14:54, 26 April 2023

OCA — Wed, 26 Apr 2023 14:54:38 GMT

←Older revision		Revision as of 14:54, 26 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8iah is ON HOLD	+	The entry 8iah is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8iah" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2023 09:02:55 GMT

Protected "8iah" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:02, 15 February 2023

OCA: New page: '''Unreleased structure''' The entry 8iah is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Feb 2023 09:02:52 GMT

New page: '''Unreleased structure''' The entry 8iah is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8iah is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8iah - Revision history

OCA at 07:34, 3 May 2023

OCA at 14:54, 26 April 2023

OCA: Protected "8iah" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8iah is ON HOLD Authors: Description: Category: Unreleased Structures