OCA at 09:55, 15 March 2023

OCA — Wed, 15 Mar 2023 09:55:07 GMT

←Older revision		Revision as of 09:55, 15 March 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8id8 is ~~ON HOLD~~	+	==Cryo-EM structure of the TUG891 bound GPR120-Gi complex==
		+	<StructureSection load='8id8' size='340' side='right'caption='[[8id8]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8id8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ID8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ID8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YN9:3-{4-[(4-fluoro-4-methyl[1,1-biphenyl]-2-yl)methoxy]phenyl}propanoic+acid'>YN9</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8id8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8id8 OCA], [https://pdbe.org/8id8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8id8 RCSB], [https://www.ebi.ac.uk/pdbsum/8id8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8id8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many via engagement with more than 40 GPCRs. Searching for receptors to sense beneficial omega-3 FAs of fish oil enabled the identification of GPR120, involving with a spectrum of metabolic diseases. Here, we report six cryo-EM structures of GPR120 in complex with FA hormones or TUG891 and G(i) or G(iq) trimers. Aromatic residues inside the GPR120 ligand pocket were responsible for recognizing different double-bond positions of these FAs and connect ligand recognition to distinct effector coupling. We also investigated synthetic ligand selectivity and the structural basis of missense single nucleotide polymorphisms. We reveal how GPR120 differentiates rigid double bonds and flexible single bonds and may facilitate rational drug design targeting to GPR120.

-	~~Authors:~~ Mao, C., Xiao, P., Tao~~, X.~~, Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun~~, J~~.	+	Unsaturated bond recognition leads to biased signal in a fatty acid receptor.,Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP Science. 2023 Mar 2:eadd6220. doi: 10.1126/science.add6220. PMID:36862765<ref>PMID:36862765</ref>

-	~~Description: Cryo-EM structure~~ of the ~~TUG891 bound GPR120~~-~~Gi complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Zhang, Y~~]]	+	<div class="pdbe-citations 8id8" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Yu, X~~]]	+	== References ==
-	[[Category: ~~He, Q~~]]	+	<references/>
-	[[Category: ~~Tao, X~~]]	+	__TOC__
-	[[Category: Sun, J]]	+	</StructureSection>
-	[[Category: Xiao, P]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Zhang, C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Mao,~~ C]]	+	[[Category: He Q]]
-	[[Category: ~~Qin, J~~]]	+	[[Category: Mao C]]
		+	[[Category: Qin J]]
		+	[[Category: Sun J]]
		+	[[Category: Tao X]]
		+	[[Category: Xiao P]]
		+	[[Category: Yu X]]
		+	[[Category: Zhang C]]
		+	[[Category: Zhang Y]]

OCA: Protected "8id8" [edit=sysop:move=sysop]

OCA — Wed, 22 Feb 2023 10:38:11 GMT

Protected "8id8" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:38, 22 February 2023

OCA: New page: '''Unreleased structure''' The entry 8id8 is ON HOLD Authors: Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. Description: Cryo-EM structure of the T...

OCA — Wed, 22 Feb 2023 10:38:10 GMT

New page: '''Unreleased structure''' The entry 8id8 is ON HOLD Authors: Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. Description: Cryo-EM structure of the T...

New page

'''Unreleased structure'''

The entry 8id8 is ON HOLD

Authors: Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J.

Description: Cryo-EM structure of the TUG891 bound GPR120-Gi complex
[[Category: Unreleased Structures]]
[[Category: Zhang, Y]]
[[Category: Yu, X]]
[[Category: He, Q]]
[[Category: Tao, X]]
[[Category: Sun, J]]
[[Category: Xiao, P]]
[[Category: Zhang, C]]
[[Category: Mao, C]]
[[Category: Qin, J]]

8id8 - Revision history

OCA at 09:55, 15 March 2023

OCA: Protected "8id8" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8id8 is ON HOLD Authors: Mao, C., Xiao, P., Tao, X., Qin, J., He, Q., Zhang, C., Yu, X., Zhang, Y., Sun, J. Description: Cryo-EM structure of the T...