OCA at 09:36, 1 March 2024

OCA — Fri, 01 Mar 2024 09:36:48 GMT

←Older revision		Revision as of 09:36, 1 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8ij5 is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of Integrin AVB3==
-		+	<StructureSection load='8ij5' size='340' side='right'caption='[[8ij5]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~: Xi, Z., ~~Cang~~, W., ~~Yuanzhu~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ij5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IJ5 FirstGlance]. <br>
-	~~Description~~: ~~Cryo~~-~~EM structure~~ of Integrin ~~AVB3~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ij5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ij5 OCA], [https://pdbe.org/8ij5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ij5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ij5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ij5 ProSAT]</span></td></tr>
-	[[Category: Cang, W]]	+	</table>
-	[[Category: Xi, Z]]	+	== Disease ==
-	[[Category: Yuanzhu, G]]	+	[https://www.uniprot.org/uniprot/ITB3_HUMAN ITB3_HUMAN] Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:[https://omim.org/entry/273800 273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.<ref>PMID:2392682</ref> <ref>PMID:1371279</ref> <ref>PMID:1602006</ref> <ref>PMID:1438206</ref> <ref>PMID:8781422</ref> <ref>PMID:9376589</ref> <ref>PMID:9215749</ref> <ref>PMID:9790984</ref> <ref>PMID:9684783</ref> <ref>PMID:10233432</ref> <ref>PMID:11588040</ref> <ref>PMID:11897046</ref> <ref>PMID:12083483</ref> <ref>PMID:12353082</ref> <ref>PMID:15583747</ref> <ref>PMID:15634267</ref> <ref>PMID:15748237</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ITB3_HUMAN ITB3_HUMAN] Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Cang W]]
		+	[[Category: Xi Z]]
		+	[[Category: Yuanzhu G]]

OCA at 18:42, 12 April 2023

OCA — Wed, 12 Apr 2023 18:42:37 GMT

←Older revision		Revision as of 18:42, 12 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ij5 is ON HOLD	+	The entry 8ij5 is ON HOLD until Paper Publication

	Authors: Xi, Z., Cang, W., Yuanzhu, G.		Authors: Xi, Z., Cang, W., Yuanzhu, G.

OCA: Protected "8ij5" [edit=sysop:move=sysop]

OCA — Wed, 08 Mar 2023 05:54:15 GMT

Protected "8ij5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 8 March 2023

OCA: New page: '''Unreleased structure''' The entry 8ij5 is ON HOLD Authors: Xi, Z., Cang, W., Yuanzhu, G. Description: Cryo-EM structure of Integrin AVB3 Category: Unreleased Structures [[Catego...

OCA — Wed, 08 Mar 2023 05:54:13 GMT

New page: '''Unreleased structure''' The entry 8ij5 is ON HOLD Authors: Xi, Z., Cang, W., Yuanzhu, G. Description: Cryo-EM structure of Integrin AVB3 Category: Unreleased Structures [[Catego...

New page

'''Unreleased structure'''

The entry 8ij5 is ON HOLD

Authors: Xi, Z., Cang, W., Yuanzhu, G.

Description: Cryo-EM structure of Integrin AVB3
[[Category: Unreleased Structures]]
[[Category: Cang, W]]
[[Category: Xi, Z]]
[[Category: Yuanzhu, G]]

8ij5 - Revision history

OCA at 09:36, 1 March 2024

OCA at 18:42, 12 April 2023

OCA: Protected "8ij5" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ij5 is ON HOLD Authors: Xi, Z., Cang, W., Yuanzhu, G. Description: Cryo-EM structure of Integrin AVB3 Category: Unreleased Structures [[Catego...