OCA at 08:26, 16 August 2023

OCA — Wed, 16 Aug 2023 08:26:24 GMT

←Older revision		Revision as of 08:26, 16 August 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8iy6 is ~~ON HOLD~~	+	==ETB-Gi complex bound to Endotheline-1, focused on receptor==
		+	<StructureSection load='8iy6' size='340' side='right'caption='[[8iy6]], [[Resolution\|resolution]] 3.13Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8iy6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IY6 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.13Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iy6 OCA], [https://pdbe.org/8iy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iy6 RCSB], [https://www.ebi.ac.uk/pdbsum/8iy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iy6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EDN1_HUMAN EDN1_HUMAN] Endothelins are endothelium-derived vasoconstrictor peptides.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The endothelin ET(B) receptor is a promiscuous G-protein coupled receptor that is activated by vasoactive peptide endothelins. ET(B) signaling induces reactive astrocytes in the brain and vasorelaxation in vascular smooth muscle. Consequently, ET(B) agonists are expected to be drugs for neuroprotection and improved anti-tumor drug delivery. Here, we report the cryo-electron microscopy structure of the endothelin-1-ET(B)-G(i) complex at 2.8 A resolution, with complex assembly stabilized by a newly established method. Comparisons with the inactive ET(B) receptor structures revealed how endothelin-1 activates the ET(B) receptor. The NPxxY motif, essential for G-protein activation, is not conserved in ET(B), resulting in a unique structural change upon G-protein activation. Compared with other GPCR-G-protein complexes, ET(B) binds G(i) in the shallowest position, further expanding the diversity of G-protein binding modes. This structural information will facilitate the elucidation of G-protein activation and the rational design of ET(B) agonists.

-	~~Authors: Sano, F.K~~., ~~Akasaka~~, H., Shihoya, W., Nureki, O.	+	Cryo-EM structure of the endothelin-1-ET(B)-G(i) complex.,Sano FK, Akasaka H, Shihoya W, Nureki O Elife. 2023 Apr 25;12:e85821. doi: 10.7554/eLife.85821. PMID:37096326<ref>PMID:37096326</ref>

-	~~Description: ETB~~-~~Gi complex bound to Endotheline~~-~~1, focused on receptor~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Nureki, O~~]]	+	<div class="pdbe-citations 8iy6" style="background-color:#fffaf0;"></div>
-	[[Category: Akasaka, H]]	+	== References ==
-	[[Category: Sano~~, F.K~~]]	+	<references/>
-	[[Category: Shihoya, W]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Akasaka H]]
		+	[[Category: Nureki O]]
		+	[[Category: Sano FK]]
		+	[[Category: Shihoya W]]

OCA: Protected "8iy6" [edit=sysop:move=sysop]

OCA — Wed, 12 Apr 2023 18:49:35 GMT

Protected "8iy6" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:49, 12 April 2023

OCA: New page: '''Unreleased structure''' The entry 8iy6 is ON HOLD Authors: Sano, F.K., Akasaka, H., Shihoya, W., Nureki, O. Description: ETB-Gi complex bound to Endotheline-1, focused on receptor [...

OCA — Wed, 12 Apr 2023 18:49:34 GMT

New page: '''Unreleased structure''' The entry 8iy6 is ON HOLD Authors: Sano, F.K., Akasaka, H., Shihoya, W., Nureki, O. Description: ETB-Gi complex bound to Endotheline-1, focused on receptor [...

New page

'''Unreleased structure'''

The entry 8iy6 is ON HOLD

Authors: Sano, F.K., Akasaka, H., Shihoya, W., Nureki, O.

Description: ETB-Gi complex bound to Endotheline-1, focused on receptor
[[Category: Unreleased Structures]]
[[Category: Nureki, O]]
[[Category: Akasaka, H]]
[[Category: Sano, F.K]]
[[Category: Shihoya, W]]

8iy6 - Revision history

OCA at 08:26, 16 August 2023

OCA: Protected "8iy6" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8iy6 is ON HOLD Authors: Sano, F.K., Akasaka, H., Shihoya, W., Nureki, O. Description: ETB-Gi complex bound to Endotheline-1, focused on receptor [...