OCA at 08:01, 6 December 2023

OCA — Wed, 06 Dec 2023 08:01:33 GMT

←Older revision		Revision as of 08:01, 6 December 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8j05 is ~~ON HOLD until Paper~~ Publication	+	==Human KCNQ2-CaM complex in the presence of PIP2==
		+	<StructureSection load='8j05' size='340' side='right'caption='[[8j05]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8j05]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J05 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j05 OCA], [https://pdbe.org/8j05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j05 RCSB], [https://www.ebi.ac.uk/pdbsum/8j05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j05 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KCNQ2_HUMAN KCNQ2_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can be activated by analgesics and antiepileptic drugs but their activation mechanisms remain unclear. Here we report cryo-electron microscopy (cryo-EM) structures of human KCNQ2-CaM in complex with three activators, namely the antiepileptic drug cannabidiol (CBD), the lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)), and HN37 (pynegabine), an antiepileptic drug in the clinical trial, in an either closed or open conformation. The activator-bound structures, along with electrophysiology analyses, reveal the binding modes of two CBD, one PIP(2), and two HN37 molecules in each KCNQ2 subunit, and elucidate their activation mechanisms on the KCNQ2 channel. These structures may guide the development of antiepileptic drugs and analgesics that target KCNQ2.

-	~~Authors~~:	+	Ligand activation mechanisms of human KCNQ2 channel.,Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J Nat Commun. 2023 Oct 19;14(1):6632. doi: 10.1038/s41467-023-42416-x. PMID:37857637<ref>PMID:37857637</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8j05" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Guo J]]
		+	[[Category: Li X]]
		+	[[Category: Ma D]]

OCA at 05:29, 18 May 2023

OCA — Thu, 18 May 2023 05:29:34 GMT

←Older revision		Revision as of 05:29, 18 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j05 is ON HOLD	+	The entry 8j05 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8j05" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2023 07:58:24 GMT

Protected "8j05" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:58, 19 April 2023

OCA: New page: '''Unreleased structure''' The entry 8j05 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Apr 2023 07:58:23 GMT

New page: '''Unreleased structure''' The entry 8j05 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8j05 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8j05 - Revision history

OCA at 08:01, 6 December 2023

OCA at 05:29, 18 May 2023

OCA: Protected "8j05" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8j05 is ON HOLD Authors: Description: Category: Unreleased Structures