8j0h - Revision history

OCA at 19:55, 29 May 2024

OCA — Wed, 29 May 2024 19:55:11 GMT

←Older revision		Revision as of 19:55, 29 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/YAY6_SCHPO YAY6_SCHPO]		[https://www.uniprot.org/uniprot/YAY6_SCHPO YAY6_SCHPO]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heterochromatin is generally associated with the nuclear periphery, but how the spatial organization of heterochromatin is regulated to ensure epigenetic silencing remains unclear. Here we found that Sad1, an inner nuclear membrane SUN-family protein in fission yeast, interacts with histone H2A-H2B but not H3-H4. We solved the crystal structure of the histone binding motif (HBM) of Sad1 in complex with H2A-H2B, revealing the intimate contacts between Sad1(HBM) and H2A-H2B. Structure-based mutagenesis studies revealed that the H2A-H2B-binding activity of Sad1 is required for the dynamic distribution of Sad1 throughout the nuclear envelope (NE). The Sad1-H2A-H2B complex mediates tethering telomeres and the mating-type locus to the NE. This complex is also important for heterochromatin silencing. Mechanistically, H2A-H2B enhances the interaction between Sad1 and HDACs, including Clr3 and Sir2, to maintain epigenetic identity of heterochromatin. Interestingly, our results suggest that Sad1 exhibits the histone-enhanced liquid-liquid phase separation property, which helps recruit heterochromatin factors to the NE. Our results uncover an unexpected role of SUN-family proteins in heterochromatin regulation and suggest a nucleosome-independent role of H2A-H2B in regulating Sad1's functionality.
		+
		+	The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B.,Sun W, Dong Q, Li X, Gao J, Ye X, Hu C, Li F, Chen Y Nat Commun. 2024 May 21;15(1):4322. doi: 10.1038/s41467-024-48418-7. PMID:38773107<ref>PMID:38773107</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8j0h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:09, 1 November 2023

OCA — Wed, 01 Nov 2023 13:09:38 GMT

←Older revision		Revision as of 13:09, 1 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8j0h is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the fission yeast Rex1BD protein(C4H3.06)==
-		+	<StructureSection load='8j0h' size='340' side='right'caption='[[8j0h]], [[Resolution\|resolution]] 3.38Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8j0h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J0H FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.383Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j0h OCA], [https://pdbe.org/8j0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j0h RCSB], [https://www.ebi.ac.uk/pdbsum/8j0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j0h ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/YAY6_SCHPO YAY6_SCHPO]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Schizosaccharomyces pombe 972h-]]
		+	[[Category: Chen Y]]
		+	[[Category: Li J]]
		+	[[Category: Sun W]]

OCA at 03:54, 31 May 2023

OCA — Wed, 31 May 2023 03:54:50 GMT

←Older revision		Revision as of 03:54, 31 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j0h is ON HOLD	+	The entry 8j0h is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8j0h" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2023 07:58:55 GMT

Protected "8j0h" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:58, 19 April 2023

OCA: New page: '''Unreleased structure''' The entry 8j0h is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Apr 2023 07:58:54 GMT

New page: '''Unreleased structure''' The entry 8j0h is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8j0h is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]