8j1b - Revision history

OCA at 19:55, 29 May 2024

OCA — Wed, 29 May 2024 19:55:13 GMT

←Older revision		Revision as of 19:55, 29 May 2024
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	</table>		</table>
	== Function ==		== Function ==
-	[https://www.uniprot.org/uniprot/TRPV4_MOUSE TRPV4_MOUSE] Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11094154). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:12093812, PubMed:14691263, PubMed:16368742, PubMed:16571723). Also activated by heat, low pH, citrate and phorbol esters (PubMed:14691263). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (PubMed:20413591). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (PubMed:23021218). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (PubMed:23021218). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity).[UniProtKB:Q9HBA0]<ref>PMID:11094154</ref> <ref>PMID:12093812</ref> <ref>PMID:14691263</ref> <ref>PMID:16368742</ref> <ref>PMID:16571723</ref> <ref>PMID:18174177</ref> <ref>PMID:18695040</ref> <ref>PMID:20413591</ref> <ref>PMID:23021218</ref>	+	[https://www.uniprot.org/uniprot/TRPV4_MOUSE TRPV4_MOUSE] Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11094154, PubMed:12093812, PubMed:12538589). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:12093812, PubMed:14691263, PubMed:16368742, PubMed:16571723). Also activated by heat, low pH, citrate and phorbol esters (PubMed:14691263). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (PubMed:20413591). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (PubMed:23021218). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (PubMed:23021218). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (PubMed:27252474).[UniProtKB:Q9HBA0]<ref>PMID:11094154</ref> <ref>PMID:12093812</ref> <ref>PMID:12538589</ref> <ref>PMID:14691263</ref> <ref>PMID:16368742</ref> <ref>PMID:16571723</ref> <ref>PMID:18174177</ref> <ref>PMID:18695040</ref> <ref>PMID:20413591</ref> <ref>PMID:23021218</ref> <ref>PMID:27252474</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:30, 9 August 2023

OCA — Wed, 09 Aug 2023 05:30:13 GMT

←Older revision		Revision as of 05:30, 9 August 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8j1b is ~~ON HOLD until Paper Publication~~	+	==GSK101 and Ruthenium Red bound state of mTRPV4==
-		+	<StructureSection load='8j1b' size='340' side='right'caption='[[8j1b]], [[Resolution\|resolution]] 3.72Å' scene=''>
-	~~Authors~~: ~~Zhen~~, W.X., ~~Yang~~, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8j1b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J1B FirstGlance]. <br>
-	~~Description~~: ~~GSK101~~ and ~~Ruthenium Red bound state~~ of ~~mTRPV4~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.72Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R2R:ruthenium(6+)+azanide+pentaamino(oxido)ruthenium+(1/4/2)'>R2R</scene>, <scene name='pdbligand=XQ3:N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide'>XQ3</scene></td></tr>
-	[[Category: ~~Zhen, W.X~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j1b OCA], [https://pdbe.org/8j1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j1b RCSB], [https://www.ebi.ac.uk/pdbsum/8j1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j1b ProSAT]</span></td></tr>
-	[[Category: Yang, F]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRPV4_MOUSE TRPV4_MOUSE] Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11094154). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:12093812, PubMed:14691263, PubMed:16368742, PubMed:16571723). Also activated by heat, low pH, citrate and phorbol esters (PubMed:14691263). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (PubMed:20413591). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (PubMed:23021218). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (PubMed:23021218). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity).[UniProtKB:Q9HBA0]<ref>PMID:11094154</ref> <ref>PMID:12093812</ref> <ref>PMID:14691263</ref> <ref>PMID:16368742</ref> <ref>PMID:16571723</ref> <ref>PMID:18174177</ref> <ref>PMID:18695040</ref> <ref>PMID:20413591</ref> <ref>PMID:23021218</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Yang F]]
		+	[[Category: Zhen WX]]

OCA at 05:29, 18 May 2023

OCA — Thu, 18 May 2023 05:29:53 GMT

←Older revision		Revision as of 05:29, 18 May 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j1b is ON HOLD	+	The entry 8j1b is ON HOLD until Paper Publication

	Authors: Zhen, W.X., Yang, F.		Authors: Zhen, W.X., Yang, F.

OCA: Protected "8j1b" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2023 08:01:22 GMT

Protected "8j1b" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:01, 19 April 2023

OCA: New page: '''Unreleased structure''' The entry 8j1b is ON HOLD Authors: Zhen, W.X., Yang, F. Description: GSK101 and Ruthenium Red bound state of mTRPV4 Category: Unreleased Structures [[Cat...

OCA — Wed, 19 Apr 2023 08:01:20 GMT

New page: '''Unreleased structure''' The entry 8j1b is ON HOLD Authors: Zhen, W.X., Yang, F. Description: GSK101 and Ruthenium Red bound state of mTRPV4 Category: Unreleased Structures [[Cat...

New page

'''Unreleased structure'''

The entry 8j1b is ON HOLD

Authors: Zhen, W.X., Yang, F.

Description: GSK101 and Ruthenium Red bound state of mTRPV4
[[Category: Unreleased Structures]]
[[Category: Zhen, W.X]]
[[Category: Yang, F]]