8j75 - Revision history

OCA at 07:59, 10 April 2024

OCA — Wed, 10 Apr 2024 07:59:50 GMT

←Older revision		Revision as of 07:59, 10 April 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8j75 is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, monomeric state==
-		+	<StructureSection load='8j75' size='340' side='right'caption='[[8j75]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8j75]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J75 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=HC6:(2S,2S)-2,2-BIPHENYL-4,4-DIYLBIS(2-HYDROXY-4,4-DIMETHYLMORPHOLIN-4-IUM)'>HC6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j75 OCA], [https://pdbe.org/8j75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j75 RCSB], [https://www.ebi.ac.uk/pdbsum/8j75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j75 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SC5A7_HUMAN SC5A7_HUMAN] Distal hereditary motor neuropathy type 7;Presynaptic congenital myasthenic syndromes. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SC5A7_HUMAN SC5A7_HUMAN] High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:11027560, PubMed:11068039, PubMed:12969261, PubMed:17005849, PubMed:23141292, PubMed:23132865, PubMed:12237312, PubMed:27569547). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (PubMed:17005849). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (PubMed:11068039, PubMed:17005849, PubMed:12237312). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (PubMed:27569547). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed:11027560). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (PubMed:12969261, PubMed:15953352).<ref>PMID:11027560</ref> <ref>PMID:11068039</ref> <ref>PMID:12237312</ref> <ref>PMID:12969261</ref> <ref>PMID:15953352</ref> <ref>PMID:17005849</ref> <ref>PMID:23132865</ref> <ref>PMID:23141292</ref> <ref>PMID:27569547</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Gao Y]]
		+	[[Category: Qiu Y]]
		+	[[Category: Zhao Y]]

OCA at 06:12, 29 November 2023

OCA — Wed, 29 Nov 2023 06:12:49 GMT

←Older revision		Revision as of 06:12, 29 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j75 is ON HOLD	+	The entry 8j75 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:32, 22 November 2023

OCA — Wed, 22 Nov 2023 05:32:26 GMT

←Older revision		Revision as of 05:32, 22 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j75 is ON HOLD ~~until Paper Publication~~	+	The entry 8j75 is ON HOLD

	Authors:		Authors:

OCA at 05:05, 15 November 2023

OCA — Wed, 15 Nov 2023 05:05:24 GMT

←Older revision		Revision as of 05:05, 15 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j75 is ON HOLD	+	The entry 8j75 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 11:51, 20 September 2023

OCA — Wed, 20 Sep 2023 11:51:32 GMT

←Older revision		Revision as of 11:51, 20 September 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j75 is ON HOLD ~~until Paper Publication~~	+	The entry 8j75 is ON HOLD

	Authors:		Authors:

OCA at 02:24, 25 May 2023

OCA — Thu, 25 May 2023 02:24:21 GMT

←Older revision		Revision as of 02:24, 25 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j75 is ON HOLD	+	The entry 8j75 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8j75" [edit=sysop:move=sysop]

OCA — Wed, 03 May 2023 05:34:56 GMT

Protected "8j75" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:34, 3 May 2023

OCA: New page: '''Unreleased structure''' The entry 8j75 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 May 2023 05:34:55 GMT

New page: '''Unreleased structure''' The entry 8j75 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8j75 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]