OCA at 11:44, 13 December 2023

OCA — Wed, 13 Dec 2023 11:44:53 GMT

←Older revision		Revision as of 11:44, 13 December 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8j8t is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of calcium-saturated SRCR domain 11 of DMBT1==
-		+	<StructureSection load='8j8t' size='340' side='right'caption='[[8j8t]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	~~Authors~~: ~~Zhang~~, C., Lu, P., ~~Nagata~~, K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8j8t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J8T FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of calcium-~~saturated SRCR domain 11~~ of ~~DMBT1~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[Category: ~~Nagata, K~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j8t OCA], [https://pdbe.org/8j8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j8t RCSB], [https://www.ebi.ac.uk/pdbsum/8j8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j8t ProSAT]</span></td></tr>
-	[[Category: Lu, P]]	+	</table>
-	[[Category: Zhang, C]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/DMBT1_HUMAN DMBT1_HUMAN] The gene represented in this entry is involved in disease pathogenesis. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DMBT1_HUMAN DMBT1_HUMAN] May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.<ref>PMID:10485905</ref> <ref>PMID:11007786</ref> <ref>PMID:11751412</ref> <ref>PMID:16796526</ref> <ref>PMID:17548659</ref> <ref>PMID:17709527</ref> <ref>PMID:19189310</ref> <ref>PMID:9288095</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Lu P]]
		+	[[Category: Nagata K]]
		+	[[Category: Zhang C]]

OCA at 06:21, 14 June 2023

OCA — Wed, 14 Jun 2023 06:21:23 GMT

←Older revision		Revision as of 06:21, 14 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8j8t is ON HOLD	+	The entry 8j8t is ON HOLD until Paper Publication

	Authors: Zhang, C., Lu, P., Nagata, K.		Authors: Zhang, C., Lu, P., Nagata, K.

OCA at 05:31, 18 May 2023

OCA — Thu, 18 May 2023 05:31:06 GMT

←Older revision		Revision as of 05:31, 18 May 2023
Line 3:		Line 3:
	The entry 8j8t is ON HOLD		The entry 8j8t is ON HOLD

-	Authors: ~~Changyu~~, Z., ~~Peng~~, L., ~~Koji~~, N.	+	Authors: Zhang, C., Lu, P., Nagata, K.

	Description: Crystal structure of calcium-saturated SRCR domain 11 of DMBT1		Description: Crystal structure of calcium-saturated SRCR domain 11 of DMBT1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Peng~~, L]]	+	[[Category: Nagata, K]]
-	[[Category: ~~Changyu~~, Z]]	+	[[Category: Lu, P]]
-	[[Category: ~~Koji~~, N]]	+	[[Category: Zhang, C]]

OCA: Protected "8j8t" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2023 05:08:51 GMT

Protected "8j8t" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 10 May 2023

OCA: New page: '''Unreleased structure''' The entry 8j8t is ON HOLD Authors: Changyu, Z., Peng, L., Koji, N. Description: Crystal structure of calcium-saturated SRCR domain 11 of DMBT1 [[Category: Un...

OCA — Wed, 10 May 2023 05:08:50 GMT

New page: '''Unreleased structure''' The entry 8j8t is ON HOLD Authors: Changyu, Z., Peng, L., Koji, N. Description: Crystal structure of calcium-saturated SRCR domain 11 of DMBT1 [[Category: Un...

New page

'''Unreleased structure'''

The entry 8j8t is ON HOLD

Authors: Changyu, Z., Peng, L., Koji, N.

Description: Crystal structure of calcium-saturated SRCR domain 11 of DMBT1
[[Category: Unreleased Structures]]
[[Category: Peng, L]]
[[Category: Changyu, Z]]
[[Category: Koji, N]]

8j8t - Revision history

OCA at 11:44, 13 December 2023

OCA at 06:21, 14 June 2023

OCA at 05:31, 18 May 2023

OCA: Protected "8j8t" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8j8t is ON HOLD Authors: Changyu, Z., Peng, L., Koji, N. Description: Crystal structure of calcium-saturated SRCR domain 11 of DMBT1 [[Category: Un...