8jcy - Revision history

OCA at 17:40, 18 October 2023

OCA — Wed, 18 Oct 2023 17:40:10 GMT

←Older revision		Revision as of 17:40, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8jcy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JCY FirstGlance]. <br>		<table><tr><td colspan='2'>[[8jcy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JCY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jcy OCA], [https://pdbe.org/8jcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jcy RCSB], [https://www.ebi.ac.uk/pdbsum/8jcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jcy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jcy OCA], [https://pdbe.org/8jcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jcy RCSB], [https://www.ebi.ac.uk/pdbsum/8jcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jcy ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 8jcy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 8jcy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Metabotropic glutamate receptor 3D structures\|Metabotropic glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:41, 21 June 2023

OCA — Wed, 21 Jun 2023 09:41:49 GMT

←Older revision		Revision as of 09:41, 21 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8jcy is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575 (dimerization mode I)==
		+	<StructureSection load='8jcy' size='340' side='right'caption='[[8jcy]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8jcy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JCY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jcy OCA], [https://pdbe.org/8jcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jcy RCSB], [https://www.ebi.ac.uk/pdbsum/8jcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jcy ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> [https://www.uniprot.org/uniprot/GRM2_HUMAN GRM2_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.<ref>PMID:18297054</ref> <ref>PMID:22300836</ref> <ref>PMID:23129762</ref> <ref>PMID:7620613</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heterodimerization of the metabotropic glutamate receptors (mGlus) has shown importance in the functional modulation of the receptors and offers potential drug targets for treating central nervous system diseases. However, due to a lack of molecular details of the mGlu heterodimers, understanding of the mechanisms underlying mGlu heterodimerization and activation is limited. Here we report twelve cryo-electron microscopy (cryo-EM) structures of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers in different conformational states, including inactive, intermediate inactive, intermediate active and fully active conformations. These structures provide a full picture of conformational rearrangement of mGlu2-mGlu3 upon activation. The Venus flytrap domains undergo a sequential conformational change, while the transmembrane domains exhibit a substantial rearrangement from an inactive, symmetric dimer with diverse dimerization patterns to an active, asymmetric dimer in a conserved dimerization mode. Combined with functional data, these structures reveal that stability of the inactive conformations of the subunits and the subunit-G protein interaction pattern are determinants of asymmetric signal transduction of the heterodimers. Furthermore, a novel binding site for two mGlu4 positive allosteric modulators was observed in the asymmetric dimer interfaces of the mGlu2-mGlu4 heterodimer and mGlu4 homodimer, and may serve as a drug recognition site. These findings greatly extend our knowledge about signal transduction of the mGlus.

-	~~Authors~~:	+	Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B Cell Res. 2023 Jun 8. doi: 10.1038/s41422-023-00830-2. PMID:37286794<ref>PMID:37286794</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8jcy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Feng Y]]
		+	[[Category: Han S]]
		+	[[Category: Lin S]]
		+	[[Category: Wang M]]
		+	[[Category: Wang X]]
		+	[[Category: Wu B]]
		+	[[Category: Xu T]]
		+	[[Category: Zhao Q]]

OCA at 04:12, 7 June 2023

OCA — Wed, 07 Jun 2023 04:12:59 GMT

←Older revision		Revision as of 04:12, 7 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jcy is ON HOLD	+	The entry 8jcy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8jcy" [edit=sysop:move=sysop]

OCA — Thu, 18 May 2023 05:36:21 GMT

Protected "8jcy" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 18 May 2023

OCA: New page: '''Unreleased structure''' The entry 8jcy is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 18 May 2023 05:36:20 GMT

New page: '''Unreleased structure''' The entry 8jcy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8jcy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]