OCA at 10:06, 17 January 2024

OCA — Wed, 17 Jan 2024 10:06:55 GMT

←Older revision		Revision as of 10:06, 17 January 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~8jhi~~ is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==FZD3-Gs complex==
		+	<StructureSection load='8jhi' size='340' side='right'caption='[[8jhi]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8jhi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JHI FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jhi OCA], [https://pdbe.org/8jhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jhi RCSB], [https://www.ebi.ac.uk/pdbsum/8jhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jhi ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS1_HUMAN GNAS1_HUMAN] The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS1_HUMAN GNAS1_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity).[UniProtKB:Q6R0H7]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles in embryonic development and tumorigenesis. Among these, FZD6 is closely associated with lens development. Understanding FZD activation mechanism is key to unlock these emerging targets. Here we present the cryo-EM structures of FZD6 and FZD3 which are known to relay non-canonical planar cell polarity (PCP) signaling pathways as well as FZD1 in their G protein-coupled states and in the apo inactive states, respectively. Comparison of the three inactive/active pairs unveiled a shared activation framework among all ten FZDs. Mutagenesis along with imaging and functional analysis on the human lens epithelial tissues suggested potential crosstalk between the G-protein coupling of FZD6 and the PCP signaling pathways. Together, this study provides an integrated understanding of FZD structure and function, and lays the foundation for developing therapeutic modulators to activate or inhibit FZD signaling for a range of disorders including cancers and cataracts.

-	~~Authors: Fei~~, X., ~~Zhibin~~, Z.	+	A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.,Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F Cell Discov. 2024 Jan 5;10(1):3. doi: 10.1038/s41421-023-00627-y. PMID:38182578<ref>PMID:38182578</ref>

-	~~Description: FZD3~~-~~Gs complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Fei, X~~]]	+	<div class="pdbe-citations 8jhi" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Zhibin,~~ Z]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Xu F]]
		+	[[Category: Zhang Z]]

OCA at 08:45, 20 December 2023

OCA — Wed, 20 Dec 2023 08:45:06 GMT

←Older revision		Revision as of 08:45, 20 December 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jhi is ON HOLD	+	The entry 8jhi is ON HOLD until Paper Publication

	Authors: Fei, X., Zhibin, Z.		Authors: Fei, X., Zhibin, Z.

OCA: Protected "8jhi" [edit=sysop:move=sysop]

OCA — Wed, 31 May 2023 04:03:02 GMT

Protected "8jhi" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:03, 31 May 2023

OCA: New page: '''Unreleased structure''' The entry 8jhi is ON HOLD Authors: Fei, X., Zhibin, Z. Description: FZD3-Gs complex Category: Unreleased Structures Category: Fei, X [[Category: Zhib...

OCA — Wed, 31 May 2023 04:03:00 GMT

New page: '''Unreleased structure''' The entry 8jhi is ON HOLD Authors: Fei, X., Zhibin, Z. Description: FZD3-Gs complex Category: Unreleased Structures Category: Fei, X [[Category: Zhib...

New page

'''Unreleased structure'''

The entry 8jhi is ON HOLD

Authors: Fei, X., Zhibin, Z.

Description: FZD3-Gs complex
[[Category: Unreleased Structures]]
[[Category: Fei, X]]
[[Category: Zhibin, Z]]

8jhi - Revision history

OCA at 10:06, 17 January 2024

OCA at 08:45, 20 December 2023

OCA: Protected "8jhi" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8jhi is ON HOLD Authors: Fei, X., Zhibin, Z. Description: FZD3-Gs complex Category: Unreleased Structures Category: Fei, X [[Category: Zhib...