OCA at 08:18, 20 March 2024

OCA — Wed, 20 Mar 2024 08:18:46 GMT

←Older revision		Revision as of 08:18, 20 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8ji0 is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of the TcsH-CROP in complex with TMPRSS2==
-		+	<StructureSection load='8ji0' size='340' side='right'caption='[[8ji0]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~: ~~Zhou~~, R., ~~Tao~~, L., ~~Zhan~~, X.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ji0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Paeniclostridium_sordellii Paeniclostridium sordellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JI0 FirstGlance]. <br>
-	~~Description~~: ~~Cryo~~-~~EM structure~~ of the ~~TcsH~~-~~CROP in complex with~~ TMPRSS2	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ji0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ji0 OCA], [https://pdbe.org/8ji0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ji0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ji0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ji0 ProSAT]</span></td></tr>
-	[[Category: ~~Zhan, X~~]]	+	</table>
-	[[Category: Tao, L]]	+	== Function ==
-	[[Category: Zhou, R]]	+	[https://www.uniprot.org/uniprot/TMPS2_HUMAN TMPS2_HUMAN] Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).[UniProtKB:Q9JIQ8]<ref>PMID:15537383</ref> <ref>PMID:25122198</ref> <ref>PMID:26018085</ref> (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.<ref>PMID:21068237</ref> <ref>PMID:21325420</ref> <ref>PMID:23536651</ref> <ref>PMID:23966399</ref> <ref>PMID:24027332</ref> <ref>PMID:24227843</ref> <ref>PMID:32142651</ref> <ref>PMID:32404436</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli K-12]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Paeniclostridium sordellii]]
		+	[[Category: Tao L]]
		+	[[Category: Zhan X]]
		+	[[Category: Zhou R]]

OCA at 03:56, 5 July 2023

OCA — Wed, 05 Jul 2023 03:56:09 GMT

←Older revision		Revision as of 03:56, 5 July 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ji0 is ON HOLD	+	The entry 8ji0 is ON HOLD until Paper Publication

	Authors: Zhou, R., Tao, L., Zhan, X.		Authors: Zhou, R., Tao, L., Zhan, X.

OCA: Protected "8ji0" [edit=sysop:move=sysop]

OCA — Wed, 31 May 2023 04:03:47 GMT

Protected "8ji0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:03, 31 May 2023

OCA: New page: '''Unreleased structure''' The entry 8ji0 is ON HOLD Authors: Zhou, R., Tao, L., Zhan, X. Description: Cryo-EM structure of the TcsH-CROP in complex with TMPRSS2 [[Category: Unreleased...

OCA — Wed, 31 May 2023 04:03:46 GMT

New page: '''Unreleased structure''' The entry 8ji0 is ON HOLD Authors: Zhou, R., Tao, L., Zhan, X. Description: Cryo-EM structure of the TcsH-CROP in complex with TMPRSS2 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 8ji0 is ON HOLD

Authors: Zhou, R., Tao, L., Zhan, X.

Description: Cryo-EM structure of the TcsH-CROP in complex with TMPRSS2
[[Category: Unreleased Structures]]
[[Category: Zhan, X]]
[[Category: Tao, L]]
[[Category: Zhou, R]]

8ji0 - Revision history

OCA at 08:18, 20 March 2024

OCA at 03:56, 5 July 2023

OCA: Protected "8ji0" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ji0 is ON HOLD Authors: Zhou, R., Tao, L., Zhan, X. Description: Cryo-EM structure of the TcsH-CROP in complex with TMPRSS2 [[Category: Unreleased...