OCA at 18:02, 29 May 2024

OCA — Wed, 29 May 2024 18:02:38 GMT

←Older revision		Revision as of 18:02, 29 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 8jin is ~~ON HOLD until Paper Publication~~	+	==The local refined map of XBB spike protein (S) in complex with bispecific antibody G7-Fc==
-		+	<StructureSection load='8jin' size='340' side='right'caption='[[8jin]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~Authors~~: Ma, Y., ~~Mao, Q~~., ~~Wang, Y~~., ~~Zhang~~, Z.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8jin]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JIN FirstGlance]. <br>
-	~~Description~~: ~~The local refined map~~ of ~~XBB spike~~ protein (S) in ~~complex with bispecific antibody G7~~-Fc	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jin OCA], [https://pdbe.org/8jin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jin RCSB], [https://www.ebi.ac.uk/pdbsum/8jin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jin ProSAT]</span></td></tr>
-	[[Category: ~~Zhang, Z~~]]	+	</table>
-	[[Category: ~~Wang, Y~~]]	+	== Function ==
-	[[Category: Ma, Y]]	+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
-	[[Category: Mao, Q]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Ma Y]]
		+	[[Category: Mao Q]]
		+	[[Category: Wang Y]]
		+	[[Category: Zhang Z]]

OCA at 04:36, 19 July 2023

OCA — Wed, 19 Jul 2023 04:36:44 GMT

←Older revision		Revision as of 04:36, 19 July 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jin is ON HOLD	+	The entry 8jin is ON HOLD until Paper Publication

	Authors: Ma, Y., Mao, Q., Wang, Y., Zhang, Z.		Authors: Ma, Y., Mao, Q., Wang, Y., Zhang, Z.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zhang, Z]]		[[Category: Zhang, Z]]
-	[[Category: Ma, Y]]
	[[Category: Wang, Y]]		[[Category: Wang, Y]]
		+	[[Category: Ma, Y]]
	[[Category: Mao, Q]]		[[Category: Mao, Q]]

OCA: Protected "8jin" [edit=sysop:move=sysop]

OCA — Wed, 07 Jun 2023 04:14:26 GMT

Protected "8jin" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:14, 7 June 2023

OCA: New page: '''Unreleased structure''' The entry 8jin is ON HOLD Authors: Ma, Y., Mao, Q., Wang, Y., Zhang, Z. Description: The local refined map of XBB spike protein (S) in complex with bispecifi...

OCA — Wed, 07 Jun 2023 04:14:25 GMT

New page: '''Unreleased structure''' The entry 8jin is ON HOLD Authors: Ma, Y., Mao, Q., Wang, Y., Zhang, Z. Description: The local refined map of XBB spike protein (S) in complex with bispecifi...

New page

'''Unreleased structure'''

The entry 8jin is ON HOLD

Authors: Ma, Y., Mao, Q., Wang, Y., Zhang, Z.

Description: The local refined map of XBB spike protein (S) in complex with bispecific antibody G7-Fc
[[Category: Unreleased Structures]]
[[Category: Zhang, Z]]
[[Category: Ma, Y]]
[[Category: Wang, Y]]
[[Category: Mao, Q]]

8jin - Revision history

OCA at 18:02, 29 May 2024

OCA at 04:36, 19 July 2023

OCA: Protected "8jin" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8jin is ON HOLD Authors: Ma, Y., Mao, Q., Wang, Y., Zhang, Z. Description: The local refined map of XBB spike protein (S) in complex with bispecifi...