OCA at 10:09, 27 March 2024

OCA — Wed, 27 Mar 2024 10:09:20 GMT

←Older revision		Revision as of 10:09, 27 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8jtw is ~~ON HOLD until 2025~~-06-22	+	==hOCT1 in complex with nb5660 in inward facing partially open 1 conformation==
-		+	<StructureSection load='8jtw' size='340' side='right'caption='[[8jtw]], [[Resolution\|resolution]] 3.23Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8jtw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JTW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.23Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jtw OCA], [https://pdbe.org/8jtw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jtw RCSB], [https://www.ebi.ac.uk/pdbsum/8jtw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jtw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S22A1_HUMAN S22A1_HUMAN] Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:9260930, PubMed:9187257, PubMed:11388889, PubMed:9655880, PubMed:11408531, PubMed:15389554, PubMed:16263091, PubMed:16272756, PubMed:16581093, PubMed:19536068, PubMed:21128598, PubMed:23680637, PubMed:24961373, PubMed:34040533, PubMed:12439218, PubMed:12719534). Functions as a pH- and Na(+)-independent, bidirectional transporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (By similarity). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal elimination of organic cations from the systemic circulation (PubMed:16263091). Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, histamine, neurotransmitters dopamine, serotonin and adrenaline (PubMed:9260930, PubMed:24961373, PubMed:35469921, PubMed:12439218). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (PubMed:21128598). Involved in the hepatic uptake of vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (PubMed:24961373). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with lower efficency (PubMed:17460754). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (PubMed:11907186). May contribute to the transport of cationic compounds in testes across the blood-testis-barrier (Probable). Also involved in the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:9260930, PubMed:11408531, PubMed:15389554, PubMed:35469921).[UniProtKB:O08966][UniProtKB:Q63089]<ref>PMID:11388889</ref> <ref>PMID:11408531</ref> <ref>PMID:11907186</ref> <ref>PMID:12439218</ref> <ref>PMID:12719534</ref> <ref>PMID:15389554</ref> <ref>PMID:15817714</ref> <ref>PMID:16263091</ref> <ref>PMID:16272756</ref> <ref>PMID:16581093</ref> <ref>PMID:17460754</ref> <ref>PMID:19536068</ref> <ref>PMID:21128598</ref> <ref>PMID:23680637</ref> <ref>PMID:24961373</ref> <ref>PMID:34040533</ref> <ref>PMID:35469921</ref> <ref>PMID:9187257</ref> <ref>PMID:9260930</ref> <ref>PMID:9655880</ref> <ref>PMID:35307651</ref> Mediates the uptake of 1-methyl-4-phenylpyridinium (MPP(+)).<ref>PMID:11388889</ref> Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)).<ref>PMID:11388889</ref> Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)).<ref>PMID:11388889</ref> Not able to uptake 1-methyl-4-phenylpyridinium (MPP(+)).<ref>PMID:11388889</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Lama glama]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen J]]
		+	[[Category: Chen L]]
		+	[[Category: Cheng L]]
		+	[[Category: Gao K]]
		+	[[Category: He G]]
		+	[[Category: Kong F]]
		+	[[Category: Lan B]]
		+	[[Category: Liu X]]
		+	[[Category: Yan C]]
		+	[[Category: Zhang S]]
		+	[[Category: Zhu A]]

OCA at 08:53, 2 August 2023

OCA — Wed, 02 Aug 2023 08:53:30 GMT

←Older revision		Revision as of 08:53, 2 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jtw is ON HOLD	+	The entry 8jtw is ON HOLD until 2025-06-22

	Authors:		Authors:

OCA: Protected "8jtw" [edit=sysop:move=sysop]

OCA — Wed, 28 Jun 2023 19:46:30 GMT

Protected "8jtw" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:46, 28 June 2023

OCA: New page: '''Unreleased structure''' The entry 8jtw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Jun 2023 19:46:29 GMT

New page: '''Unreleased structure''' The entry 8jtw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8jtw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8jtw - Revision history

OCA at 10:09, 27 March 2024

OCA at 08:53, 2 August 2023

OCA: Protected "8jtw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8jtw is ON HOLD Authors: Description: Category: Unreleased Structures