OCA at 14:09, 18 October 2023

OCA — Wed, 18 Oct 2023 14:09:38 GMT

←Older revision		Revision as of 14:09, 18 October 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8juy is ~~ON HOLD until Paper~~ Publication	+	==Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class II)==
		+	<StructureSection load='8juy' size='340' side='right'caption='[[8juy]], [[Resolution\|resolution]] 4.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8juy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JUY FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.34Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8juy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8juy OCA], [https://pdbe.org/8juy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8juy RCSB], [https://www.ebi.ac.uk/pdbsum/8juy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8juy ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATAD2 is a non-canonical ATP-dependent histone chaperone and a major cancer target. Despite widespread efforts to design drugs targeting the ATAD2 bromodomain, little is known about the overall structural organization and regulation of ATAD2. Here, we present the 3.1 A cryo-EM structure of human ATAD2 in the ATP state, showing a shallow hexameric spiral that binds a peptide substrate at the central pore. The spiral conformation is locked by an N-terminal linker domain (LD) that wedges between the seam subunits, thus limiting ATP-dependent symmetry breaking of the AAA+ ring. In contrast, structures of the ATAD2-histone H3/H4 complex show the LD undocked from the seam, suggesting that H3/H4 binding unlocks the AAA+ spiral by allosterically releasing the LD. These findings, together with the discovery of an inter-subunit signaling mechanism, reveal a unique regulatory mechanism for ATAD2 and lay the foundation for developing new ATAD2 inhibitors.

-	~~Authors:~~ Cho, C., ~~Song~~, J.	+	Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication.,Cho C, Ganser C, Uchihashi T, Kato K, Song JJ Commun Biol. 2023 Sep 28;6(1):993. doi: 10.1038/s42003-023-05373-1. PMID:37770645<ref>PMID:37770645</ref>

-	~~Description: Human ATAD2 Walker B mutant-H3~~/~~H4K5Q complex~~, ~~ATP state (Class II)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Song, J~~]]	+	<div class="pdbe-citations 8juy" style="background-color:#fffaf0;"></div>
-	[[Category: Cho, C]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Cho C]]
		+	[[Category: Song J]]

OCA at 04:34, 11 October 2023

OCA — Wed, 11 Oct 2023 04:34:43 GMT

←Older revision		Revision as of 04:34, 11 October 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8juy is ON HOLD	+	The entry 8juy is ON HOLD until Paper Publication

	Authors: Cho, C., Song, J.		Authors: Cho, C., Song, J.

OCA: Protected "8juy" [edit=sysop:move=sysop]

OCA — Wed, 05 Jul 2023 04:03:11 GMT

Protected "8juy" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:03, 5 July 2023

OCA: New page: '''Unreleased structure''' The entry 8juy is ON HOLD Authors: Cho, C., Song, J. Description: Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class II) [[Category: Unreleased S...

OCA — Wed, 05 Jul 2023 04:03:10 GMT

New page: '''Unreleased structure''' The entry 8juy is ON HOLD Authors: Cho, C., Song, J. Description: Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class II) [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 8juy is ON HOLD

Authors: Cho, C., Song, J.

Description: Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class II)
[[Category: Unreleased Structures]]
[[Category: Song, J]]
[[Category: Cho, C]]

8juy - Revision history

OCA at 14:09, 18 October 2023

OCA at 04:34, 11 October 2023

OCA: Protected "8juy" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8juy is ON HOLD Authors: Cho, C., Song, J. Description: Human ATAD2 Walker B mutant-H3/H4K5Q complex, ATP state (Class II) [[Category: Unreleased S...