8jyo - Revision history

OCA at 11:03, 3 January 2024

OCA — Wed, 03 Jan 2024 11:03:02 GMT

←Older revision		Revision as of 11:03, 3 January 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8jyo ~~is ON HOLD until Paper Publication~~	+	==Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (2-up state)==
-		+	<StructureSection load='8jyo' size='340' side='right'caption='[[8jyo]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~: ~~Yajima, H~~.~~, Anraku, Y~~.~~, Kita, S~~., ~~Kimura, K~~., ~~Sasaki~~, J., ~~Sasaki~~-~~Tabata~~, K., ~~Maenaka~~, K., ~~Hashiguchi, T~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8jyo]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JYO FirstGlance]. <br>
-	~~Description~~: ~~Structure of SARS-CoV-2 XBB~~.1.~~5 spike glycoprotein in complex~~ with ACE2 (2-up state)	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Hashiguchi, T~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jyo OCA], [https://pdbe.org/8jyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jyo RCSB], [https://www.ebi.ac.uk/pdbsum/8jyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jyo ProSAT]</span></td></tr>
-	[[Category: ~~Sasaki, J~~]]	+	</table>
-	[[Category: Anraku, Y]]	+	== Function ==
-	[[Category: ~~Yajima, H~~]]	+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
-	[[Category: ~~Sasaki-Tabata,~~ K]]	+	== References ==
-	[[Category: Kita, S]]	+	<references/>
-	[[Category: Maenaka, K]]	+	__TOC__
-	[[Category: ~~Kimura,~~ K]]	+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Anraku Y]]
		+	[[Category: Hashiguchi T]]
		+	[[Category: Kimura K]]
		+	[[Category: Kita S]]
		+	[[Category: Maenaka K]]
		+	[[Category: Sasaki J]]
		+	[[Category: Sasaki-Tabata K]]
		+	[[Category: Yajima H]]

OCA at 06:28, 16 August 2023

OCA — Wed, 16 Aug 2023 06:28:58 GMT

←Older revision		Revision as of 06:28, 16 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jyo is ON HOLD	+	The entry 8jyo is ON HOLD until Paper Publication

	Authors: Yajima, H., Anraku, Y., Kita, S., Kimura, K., Sasaki, J., Sasaki-Tabata, K., Maenaka, K., Hashiguchi, T.		Authors: Yajima, H., Anraku, Y., Kita, S., Kimura, K., Sasaki, J., Sasaki-Tabata, K., Maenaka, K., Hashiguchi, T.
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	Description: Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (2-up state)		Description: Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (2-up state)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sasaki, J]]
-	[[Category: Maenaka, K]]
-	[[Category: Kimura, K]]
	[[Category: Hashiguchi, T]]		[[Category: Hashiguchi, T]]
		+	[[Category: Sasaki, J]]
	[[Category: Anraku, Y]]		[[Category: Anraku, Y]]
	[[Category: Yajima, H]]		[[Category: Yajima, H]]
	[[Category: Sasaki-Tabata, K]]		[[Category: Sasaki-Tabata, K]]
	[[Category: Kita, S]]		[[Category: Kita, S]]
		+	[[Category: Maenaka, K]]
		+	[[Category: Kimura, K]]

OCA: Protected "8jyo" [edit=sysop:move=sysop]

OCA — Wed, 12 Jul 2023 04:04:05 GMT

Protected "8jyo" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:04, 12 July 2023

OCA: New page: '''Unreleased structure''' The entry 8jyo is ON HOLD Authors: Yajima, H., Anraku, Y., Kita, S., Kimura, K., Sasaki, J., Sasaki-Tabata, K., Maenaka, K., Hashiguchi, T. Description: Stru...

OCA — Wed, 12 Jul 2023 04:04:02 GMT

New page: '''Unreleased structure''' The entry 8jyo is ON HOLD Authors: Yajima, H., Anraku, Y., Kita, S., Kimura, K., Sasaki, J., Sasaki-Tabata, K., Maenaka, K., Hashiguchi, T. Description: Stru...

New page

'''Unreleased structure'''

The entry 8jyo is ON HOLD

Authors: Yajima, H., Anraku, Y., Kita, S., Kimura, K., Sasaki, J., Sasaki-Tabata, K., Maenaka, K., Hashiguchi, T.

Description: Structure of SARS-CoV-2 XBB.1.5 spike glycoprotein in complex with ACE2 (2-up state)
[[Category: Unreleased Structures]]
[[Category: Sasaki, J]]
[[Category: Maenaka, K]]
[[Category: Kimura, K]]
[[Category: Hashiguchi, T]]
[[Category: Anraku, Y]]
[[Category: Yajima, H]]
[[Category: Sasaki-Tabata, K]]
[[Category: Kita, S]]