OCA at 07:00, 27 September 2023

OCA — Wed, 27 Sep 2023 07:00:39 GMT

←Older revision		Revision as of 07:00, 27 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8jzx is ~~ON HOLD until Paper Publication~~	+	==SLC15A4 inhibitor complex==
-		+	<StructureSection load='8jzx' size='340' side='right'caption='[[8jzx]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8jzx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JZX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Q09:2-(4-ethoxyphenyl)-N-[3-[(2R)-2-methylpiperidin-1-yl]propyl]quinoline-4-carboxamide'>Q09</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jzx OCA], [https://pdbe.org/8jzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jzx RCSB], [https://www.ebi.ac.uk/pdbsum/8jzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jzx ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S15A4_HUMAN S15A4_HUMAN] Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:16289537, PubMed:25238095, PubMed:29224352). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29224352, PubMed:31073693). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:25238095, PubMed:29224352). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:25238095). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (PubMed:32433612). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity).[UniProtKB:O09014][UniProtKB:Q91W98]<ref>PMID:16289537</ref> <ref>PMID:25238095</ref> <ref>PMID:29224352</ref> <ref>PMID:31073693</ref> <ref>PMID:32433612</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen XD]]
		+	[[Category: Xie M]]
		+	[[Category: Zhang SS]]

OCA at 06:29, 16 August 2023

OCA — Wed, 16 Aug 2023 06:29:37 GMT

←Older revision		Revision as of 06:29, 16 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8jzx is ON HOLD	+	The entry 8jzx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8jzx" [edit=sysop:move=sysop]

OCA — Wed, 12 Jul 2023 04:08:56 GMT

Protected "8jzx" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 12 July 2023

OCA: New page: '''Unreleased structure''' The entry 8jzx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jul 2023 04:08:53 GMT

New page: '''Unreleased structure''' The entry 8jzx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8jzx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8jzx - Revision history

OCA at 07:00, 27 September 2023

OCA at 06:29, 16 August 2023

OCA: Protected "8jzx" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8jzx is ON HOLD Authors: Description: Category: Unreleased Structures