OCA at 07:29, 22 November 2023

OCA — Wed, 22 Nov 2023 07:29:37 GMT

←Older revision		Revision as of 07:29, 22 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8k5c is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of Acipimox bound human hydroxy-carboxylic acid receptor 2 (Local refinement)==
-		+	<StructureSection load='8k5c' size='340' side='right'caption='[[8k5c]], [[Resolution\|resolution]] 3.13Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8k5c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8K5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8K5C FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.13Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OJX:5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic+acid'>OJX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8k5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8k5c OCA], [https://pdbe.org/8k5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8k5c RCSB], [https://www.ebi.ac.uk/pdbsum/8k5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8k5c ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HCAR2_HUMAN HCAR2_HUMAN] Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.<ref>PMID:17932499</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Ishimoto N]]
		+	[[Category: Park JH]]
		+	[[Category: Park SY]]

OCA at 07:11, 30 August 2023

OCA — Wed, 30 Aug 2023 07:11:46 GMT

←Older revision		Revision as of 07:11, 30 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8k5c is ON HOLD	+	The entry 8k5c is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8k5c" [edit=sysop:move=sysop]

OCA — Wed, 26 Jul 2023 10:51:55 GMT

Protected "8k5c" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:51, 26 July 2023

OCA: New page: '''Unreleased structure''' The entry 8k5c is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Jul 2023 10:51:54 GMT

New page: '''Unreleased structure''' The entry 8k5c is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8k5c is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8k5c - Revision history

OCA at 07:29, 22 November 2023

OCA at 07:11, 30 August 2023

OCA: Protected "8k5c" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8k5c is ON HOLD Authors: Description: Category: Unreleased Structures