8oga - Revision history

OCA at 11:14, 2 August 2023

OCA — Wed, 02 Aug 2023 11:14:11 GMT

←Older revision		Revision as of 11:14, 2 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8oga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OGA FirstGlance]. <br>		<table><tr><td colspan='2'>[[8oga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OGA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=VLW:5-[1-(4-methoxyphenyl)cyclopropyl]-8-(4-methylpiperazin-1-yl)-2,3-dihydro-1~{H}-imidazo[2,1-a]isoquinoline'>VLW</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=VLW:5-[1-(4-methoxyphenyl)cyclopropyl]-8-(4-methylpiperazin-1-yl)-2,3-dihydro-1~{H}-imidazo[2,1-a]isoquinoline'>VLW</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oga OCA], [https://pdbe.org/8oga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oga RCSB], [https://www.ebi.ac.uk/pdbsum/8oga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oga ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oga OCA], [https://pdbe.org/8oga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oga RCSB], [https://www.ebi.ac.uk/pdbsum/8oga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oga ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:21, 14 June 2023

OCA — Wed, 14 Jun 2023 08:21:41 GMT

←Older revision		Revision as of 08:21, 14 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8oga is ~~ON HOLD until 2025~~-03-19	+	==Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 6==
-		+	<StructureSection load='8oga' size='340' side='right'caption='[[8oga]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~: ~~Schroeder~~, M., ~~Vulpetti~~, A., ~~Renatus~~, M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8oga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OGA FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~human~~ DCAF1 ~~WD40 repeats~~ (~~Q1250L~~) in complex with ~~compound 6~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=VLW:5-[1-(4-methoxyphenyl)cyclopropyl]-8-(4-methylpiperazin-1-yl)-2,3-dihydro-1~{H}-imidazo[2,1-a]isoquinoline'>VLW</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oga OCA], [https://pdbe.org/8oga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oga RCSB], [https://www.ebi.ac.uk/pdbsum/8oga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oga ProSAT]</span></td></tr>
-	[[Category: ~~Vulpetti, A~~]]	+	</table>
-	[[Category: Renatus, M]]	+	== Function ==
-	[[Category: Schroeder, M]]	+	[https://www.uniprot.org/uniprot/DCAF1_HUMAN DCAF1_HUMAN] Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714).<ref>PMID:16964240</ref> <ref>PMID:17609381</ref> <ref>PMID:17630831</ref> <ref>PMID:18332868</ref> <ref>PMID:18524771</ref> <ref>PMID:18606781</ref> <ref>PMID:19287380</ref> <ref>PMID:20644714</ref> <ref>PMID:22184063</ref> <ref>PMID:23063525</ref> <ref>PMID:23362280</ref> <ref>PMID:24140421</ref> (Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT.<ref>PMID:17314515</ref> <ref>PMID:17559673</ref> <ref>PMID:17609381</ref> <ref>PMID:17620334</ref> <ref>PMID:17626091</ref> <ref>PMID:17630831</ref> <ref>PMID:18524771</ref> <ref>PMID:24116224</ref> (Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.<ref>PMID:17314515</ref> <ref>PMID:18464893</ref> <ref>PMID:19264781</ref> <ref>PMID:19923175</ref> <ref>PMID:24336198</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Renatus M]]
		+	[[Category: Schroeder M]]
		+	[[Category: Vulpetti A]]

OCA at 08:05, 19 April 2023

OCA — Wed, 19 Apr 2023 08:05:36 GMT

←Older revision		Revision as of 08:05, 19 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8oga is ON HOLD	+	The entry 8oga is ON HOLD until 2025-03-19

	Authors: Schroeder, M., Vulpetti, A., Renatus, M.		Authors: Schroeder, M., Vulpetti, A., Renatus, M.

OCA: Protected "8oga" [edit=sysop:move=sysop]

OCA — Wed, 29 Mar 2023 05:04:51 GMT

Protected "8oga" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 29 March 2023

OCA: New page: '''Unreleased structure''' The entry 8oga is ON HOLD Authors: Schroeder, M., Vulpetti, A., Renatus, M. Description: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex wi...

OCA — Wed, 29 Mar 2023 05:04:50 GMT

New page: '''Unreleased structure''' The entry 8oga is ON HOLD Authors: Schroeder, M., Vulpetti, A., Renatus, M. Description: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex wi...

New page

'''Unreleased structure'''

The entry 8oga is ON HOLD

Authors: Schroeder, M., Vulpetti, A., Renatus, M.

Description: Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 6
[[Category: Unreleased Structures]]
[[Category: Vulpetti, A]]
[[Category: Renatus, M]]
[[Category: Schroeder, M]]