OCA at 05:48, 3 April 2024

OCA — Wed, 03 Apr 2024 05:48:17 GMT

←Older revision		Revision as of 05:48, 3 April 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8oio ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide==
-		+	<StructureSection load='8oio' size='340' side='right'caption='[[8oio]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~Authors~~: ~~Dalietou, E~~.V., ~~Chen, Z~~., ~~Ramdass~~, A.E., ~~Manning~~, C., ~~Richardson~~, W., ~~Aitmakhanova, K~~., ~~Platt, M~~., ~~Pike~~, A., ~~Fedorov~~, O., ~~Brennan, P~~., ~~Bullock~~, ~~A.N~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8oio]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OIO FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.954Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Manning, C~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oio OCA], [https://pdbe.org/8oio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oio RCSB], [https://www.ebi.ac.uk/pdbsum/8oio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oio ProSAT]</span></td></tr>
-	[[Category: ~~Pike, A~~]]	+	</table>
-	[[Category: ~~Aitmakhanova, K~~]]	+	== Function ==
-	[[Category: ~~Dalietou, E.V~~]]	+	[https://www.uniprot.org/uniprot/KLH12_HUMAN KLH12_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508).<ref>PMID:16547521</ref> <ref>PMID:18303015</ref> <ref>PMID:20100572</ref> <ref>PMID:22358839</ref> <ref>PMID:27565346</ref> <ref>PMID:27716508</ref>
-	[[Category: ~~Fedorov, O~~]]	+	== References ==
-	[[Category: ~~Chen, Z~~]]	+	<references/>
-	[[Category: ~~Richardson, W~~]]	+	__TOC__
-	[[Category: ~~Ramdass,~~ A.E]]	+	</StructureSection>
-	[[Category: ~~Brennan, P~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Platt, M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bullock, A.N~~]]	+	[[Category: Aitmakhanova K]]
		+	[[Category: Brennan P]]
		+	[[Category: Bullock AN]]
		+	[[Category: Chen Z]]
		+	[[Category: Dalietou EV]]
		+	[[Category: Fedorov O]]
		+	[[Category: Manning C]]
		+	[[Category: Pike A]]
		+	[[Category: Platt M]]
		+	[[Category: Ramdass AE]]
		+	[[Category: Richardson W]]

OCA at 02:31, 25 May 2023

OCA — Thu, 25 May 2023 02:31:25 GMT

←Older revision		Revision as of 02:31, 25 May 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8oio is ON HOLD	+	The entry 8oio is ON HOLD until Paper Publication

	Authors: Dalietou, E.V., Chen, Z., Ramdass, A.E., Manning, C., Richardson, W., Aitmakhanova, K., Platt, M., Pike, A., Fedorov, O., Brennan, P., Bullock, A.N.		Authors: Dalietou, E.V., Chen, Z., Ramdass, A.E., Manning, C., Richardson, W., Aitmakhanova, K., Platt, M., Pike, A., Fedorov, O., Brennan, P., Bullock, A.N.

OCA: Protected "8oio" [edit=sysop:move=sysop]

OCA — Wed, 29 Mar 2023 05:11:20 GMT

Protected "8oio" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:11, 29 March 2023

OCA: New page: '''Unreleased structure''' The entry 8oio is ON HOLD Authors: Dalietou, E.V., Chen, Z., Ramdass, A.E., Manning, C., Richardson, W., Aitmakhanova, K., Platt, M., Pike, A., Fedorov, O., B...

OCA — Wed, 29 Mar 2023 05:11:19 GMT

New page: '''Unreleased structure''' The entry 8oio is ON HOLD Authors: Dalietou, E.V., Chen, Z., Ramdass, A.E., Manning, C., Richardson, W., Aitmakhanova, K., Platt, M., Pike, A., Fedorov, O., B...

New page

'''Unreleased structure'''

The entry 8oio is ON HOLD

Authors: Dalietou, E.V., Chen, Z., Ramdass, A.E., Manning, C., Richardson, W., Aitmakhanova, K., Platt, M., Pike, A., Fedorov, O., Brennan, P., Bullock, A.N.

Description: Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide
[[Category: Unreleased Structures]]
[[Category: Manning, C]]
[[Category: Pike, A]]
[[Category: Aitmakhanova, K]]
[[Category: Dalietou, E.V]]
[[Category: Fedorov, O]]
[[Category: Chen, Z]]
[[Category: Richardson, W]]
[[Category: Ramdass, A.E]]
[[Category: Brennan, P]]
[[Category: Platt, M]]
[[Category: Bullock, A.N]]

8oio - Revision history

OCA at 05:48, 3 April 2024

OCA at 02:31, 25 May 2023

OCA: Protected "8oio" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8oio is ON HOLD Authors: Dalietou, E.V., Chen, Z., Ramdass, A.E., Manning, C., Richardson, W., Aitmakhanova, K., Platt, M., Pike, A., Fedorov, O., B...