OCA at 08:00, 10 April 2024

OCA — Wed, 10 Apr 2024 08:00:44 GMT

←Older revision		Revision as of 08:00, 10 April 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8okj is ~~ON HOLD until Paper Publication~~	+	==Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl inhibitor AKI_12==
-		+	<StructureSection load='8okj' size='340' side='right'caption='[[8okj]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	~~Authors~~: ~~Brynda~~, J., ~~Rezacova~~, P.M., ~~Kudova~~, E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8okj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OKJ FirstGlance]. <br>
-	~~Description~~: ~~Carbonic Anhydrase IX like mutant~~ in ~~Complex~~ with ~~Steriod_Sulphamoyl inhibitor AKI_12~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VRI:[(3~{R},5~{S},8~{R},9~{S},10~{S},13~{S},14~{S},17~{S})-17-ethanoyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl]+sulfamate'>VRI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Rezacova, P.M~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8okj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8okj OCA], [https://pdbe.org/8okj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8okj RCSB], [https://www.ebi.ac.uk/pdbsum/8okj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8okj ProSAT]</span></td></tr>
-	[[Category: Kudova, E]]	+	</table>
-	[[Category: ~~Brynda, J~~]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Brynda J]]
		+	[[Category: Kudova E]]
		+	[[Category: Rezacova PM]]

OCA at 05:39, 3 May 2023

OCA — Wed, 03 May 2023 05:39:50 GMT

←Older revision		Revision as of 05:39, 3 May 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8okj is ON HOLD	+	The entry 8okj is ON HOLD until Paper Publication

	Authors: Brynda, J., Rezacova, P.M., Kudova, E.		Authors: Brynda, J., Rezacova, P.M., Kudova, E.

OCA: Protected "8okj" [edit=sysop:move=sysop]

OCA — Fri, 07 Apr 2023 05:10:51 GMT

Protected "8okj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:10, 7 April 2023

OCA: New page: '''Unreleased structure''' The entry 8okj is ON HOLD Authors: Brynda, J., Rezacova, P.M., Kudova, E. Description: Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl i...

OCA — Fri, 07 Apr 2023 05:10:50 GMT

New page: '''Unreleased structure''' The entry 8okj is ON HOLD Authors: Brynda, J., Rezacova, P.M., Kudova, E. Description: Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl i...

New page

'''Unreleased structure'''

The entry 8okj is ON HOLD

Authors: Brynda, J., Rezacova, P.M., Kudova, E.

Description: Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl inhibitor AKI_12
[[Category: Unreleased Structures]]
[[Category: Rezacova, P.M]]
[[Category: Kudova, E]]
[[Category: Brynda, J]]

8okj - Revision history

OCA at 08:00, 10 April 2024

OCA at 05:39, 3 May 2023

OCA: Protected "8okj" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8okj is ON HOLD Authors: Brynda, J., Rezacova, P.M., Kudova, E. Description: Carbonic Anhydrase IX like mutant in Complex with Steriod_Sulphamoyl i...