8op1 - Revision history

OCA at 07:00, 27 September 2023

OCA — Wed, 27 Sep 2023 07:00:52 GMT

←Older revision		Revision as of 07:00, 27 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8op1 is ~~ON HOLD until Paper~~ Publication	+	==Subsection of a helical nucleocapsid of the Respiratory Syncytial Virus==
		+	<StructureSection load='8op1' size='340' side='right'caption='[[8op1]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8op1]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Respiratory_syncytial_virus Respiratory syncytial virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OP1 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8op1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8op1 OCA], [https://pdbe.org/8op1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8op1 RCSB], [https://www.ebi.ac.uk/pdbsum/8op1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8op1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C3UPA9_9MONO C3UPA9_9MONO] Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.[RuleBase:RU363106]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human Respiratory Syncytial Virus (HRSV) is a prevalent cause of severe respiratory infections in children and the elderly. The helical HRSV nucleocapsid is a template for the viral RNA synthesis and a scaffold for the virion assembly. This cryo-electron microscopy analysis reveals the non-canonical arrangement of the HRSV nucleocapsid helix, composed of 16 nucleoproteins per asymmetric unit, and the resulting systematic variations in the RNA accessibility. We demonstrate that this unique helical symmetry originates from longitudinal interactions by the C-terminal arm of the HRSV nucleoprotein. We explore the polymorphism of the nucleocapsid-like assemblies, report five structures of the full-length particles and two alternative arrangements formed by a C-terminally truncated nucleoprotein mutant, and demonstrate the functional importance of the identified longitudinal interfaces. We put all these findings in the context of the HRSV RNA synthesis machinery and delineate the structural basis for its further investigation.

-	~~Authors: Gonnin~~, L., Desfosses, A., ~~Eleouet~~, ~~J.F.~~, Galloux, M., ~~Gutsche~~, I.	+	Structural landscape of the respiratory syncytial virus nucleocapsids.,Gonnin L, Desfosses A, Bacia-Verloop M, Chevret D, Galloux M, Eleouet JF, Gutsche I Nat Commun. 2023 Sep 15;14(1):5732. doi: 10.1038/s41467-023-41439-8. PMID:37714861<ref>PMID:37714861</ref>

-	~~Description: Subsection of~~ a ~~helical nucleocapsid~~ of the ~~Respiratory Syncytial Virus~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Gonnin, L~~]]	+	<div class="pdbe-citations 8op1" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Eleouet, J.F~~]]	+	== References ==
-	[[Category: ~~Gutsche, I~~]]	+	<references/>
-	[[Category: Galloux, M]]	+	__TOC__
-	[[Category: ~~Desfosses, A~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Respiratory syncytial virus]]
		+	[[Category: Desfosses A]]
		+	[[Category: Eleouet JF]]
		+	[[Category: Galloux M]]
		+	[[Category: Gonnin L]]
		+	[[Category: Gutsche I]]

OCA at 04:00, 9 August 2023

OCA — Wed, 09 Aug 2023 04:00:23 GMT

←Older revision		Revision as of 04:00, 9 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8op1 is ON HOLD	+	The entry 8op1 is ON HOLD until Paper Publication

	Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Galloux, M., Gutsche, I.		Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Galloux, M., Gutsche, I.

OCA at 04:07, 5 July 2023

OCA — Wed, 05 Jul 2023 04:07:39 GMT

←Older revision		Revision as of 04:07, 5 July 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8op1 is ON HOLD ~~until Paper Publication~~	+	The entry 8op1 is ON HOLD

-	Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Gutsche, I.	+	Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Galloux, M., Gutsche, I.

	Description: Subsection of a helical nucleocapsid of the Respiratory Syncytial Virus		Description: Subsection of a helical nucleocapsid of the Respiratory Syncytial Virus
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	[[Category: Eleouet, J.F]]		[[Category: Eleouet, J.F]]
	[[Category: Gutsche, I]]		[[Category: Gutsche, I]]
		+	[[Category: Galloux, M]]
	[[Category: Desfosses, A]]		[[Category: Desfosses, A]]

OCA at 08:08, 19 April 2023

OCA — Wed, 19 Apr 2023 08:08:43 GMT

←Older revision		Revision as of 08:08, 19 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8op1 is ON HOLD	+	The entry 8op1 is ON HOLD until Paper Publication

	Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Gutsche, I.		Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Gutsche, I.

OCA: Protected "8op1" [edit=sysop:move=sysop]

OCA — Wed, 12 Apr 2023 19:02:26 GMT

Protected "8op1" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:02, 12 April 2023

OCA: New page: '''Unreleased structure''' The entry 8op1 is ON HOLD Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Gutsche, I. Description: Subsection of a helical nucleocapsid of the Respiratory...

OCA — Wed, 12 Apr 2023 19:02:25 GMT

New page: '''Unreleased structure''' The entry 8op1 is ON HOLD Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Gutsche, I. Description: Subsection of a helical nucleocapsid of the Respiratory...

New page

'''Unreleased structure'''

The entry 8op1 is ON HOLD

Authors: Gonnin, L., Desfosses, A., Eleouet, J.F., Gutsche, I.

Description: Subsection of a helical nucleocapsid of the Respiratory Syncytial Virus
[[Category: Unreleased Structures]]
[[Category: Gonnin, L]]
[[Category: Eleouet, J.F]]
[[Category: Gutsche, I]]
[[Category: Desfosses, A]]