OCA at 10:40, 2 August 2023

OCA — Wed, 02 Aug 2023 10:40:11 GMT

←Older revision		Revision as of 10:40, 2 August 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 8opn is ON HOLD until Paper Publication~~	+	==Human Coronavirus HKU1 spike glycoprotein in complex with an alpha2,8-linked 9-O-acetylated disialoside (1-up state)==
-		+	<StructureSection load='8opn' size='340' side='right'caption='[[8opn]], [[Resolution\|resolution]] 4.70Å' scene=''>
-	~~Authors: Pronker, M.F., Creutznacher, R., Hurdiss, D.L.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8opn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_HKU1 Human coronavirus HKU1] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OPN FirstGlance]. <br>
-	~~Description:~~ Human Coronavirus HKU1 spike glycoprotein in complex with an alpha2,8-linked 9-O-acetylated disialoside (1-up state)	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.7Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5N6:(2~{R},4~{S},5~{R},6~{R})-5-ACETAMIDO-6-[(1~{R},2~{R})-3-ACETYLOXY-1,2-BIS(OXIDANYL)PROPYL]-2,4-BIS(OXIDANYL)OXANE-2-CARBOXYLIC+ACID'>5N6</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	[[Category: ~~Pronker, M.F~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8opn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8opn OCA], [https://pdbe.org/8opn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8opn RCSB], [https://www.ebi.ac.uk/pdbsum/8opn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8opn ProSAT]</span></td></tr>
-	[[Category: Creutznacher, R]]	+	</table>
-	[[Category: Hurdiss~~, D.L~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/E0YJ44_CVHK1 E0YJ44_CVHK1] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099][https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human coronavirus HKU1]]
		+	[[Category: Large Structures]]
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Creutznacher R]]
		+	[[Category: Hurdiss DL]]
		+	[[Category: Pronker MF]]

OCA at 02:32, 25 May 2023

OCA — Thu, 25 May 2023 02:32:19 GMT

←Older revision		Revision as of 02:32, 25 May 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8opn is ON HOLD	+	The entry 8opn is ON HOLD until Paper Publication

	Authors: Pronker, M.F., Creutznacher, R., Hurdiss, D.L.		Authors: Pronker, M.F., Creutznacher, R., Hurdiss, D.L.

OCA: Protected "8opn" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2023 08:09:19 GMT

Protected "8opn" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:09, 19 April 2023

OCA: New page: '''Unreleased structure''' The entry 8opn is ON HOLD Authors: Pronker, M.F., Creutznacher, R., Hurdiss, D.L. Description: Human Coronavirus HKU1 spike glycoprotein in complex with an a...

OCA — Wed, 19 Apr 2023 08:09:15 GMT

New page: '''Unreleased structure''' The entry 8opn is ON HOLD Authors: Pronker, M.F., Creutznacher, R., Hurdiss, D.L. Description: Human Coronavirus HKU1 spike glycoprotein in complex with an a...

New page

'''Unreleased structure'''

The entry 8opn is ON HOLD

Authors: Pronker, M.F., Creutznacher, R., Hurdiss, D.L.

Description: Human Coronavirus HKU1 spike glycoprotein in complex with an alpha2,8-linked 9-O-acetylated disialoside (1-up state)
[[Category: Unreleased Structures]]
[[Category: Pronker, M.F]]
[[Category: Creutznacher, R]]
[[Category: Hurdiss, D.L]]

8opn - Revision history

OCA at 10:40, 2 August 2023

OCA at 02:32, 25 May 2023

OCA: Protected "8opn" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8opn is ON HOLD Authors: Pronker, M.F., Creutznacher, R., Hurdiss, D.L. Description: Human Coronavirus HKU1 spike glycoprotein in complex with an a...