8oxi - Revision history

OCA at 08:28, 16 August 2023

OCA — Wed, 16 Aug 2023 08:28:26 GMT

←Older revision		Revision as of 08:28, 16 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8oxi is ~~ON HOLD until 2025~~-05-02	+	==crystal structure of powdery mildews Blumeria graminis f. sp. tritici AVRPM2(1)==
		+	<StructureSection load='8oxi' size='340' side='right'caption='[[8oxi]], [[Resolution\|resolution]] 1.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8oxi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Blumeria_graminis_f._sp._tritici Blumeria graminis f. sp. tritici]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OXI FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.51Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oxi OCA], [https://pdbe.org/8oxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oxi RCSB], [https://www.ebi.ac.uk/pdbsum/8oxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oxi ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1L5JEG4_BLUGR A0A1L5JEG4_BLUGR]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In plants, host-pathogen coevolution often manifests in reciprocal, adaptive genetic changes through variations in host nucleotide-binding leucine-rich repeat immune receptors (NLRs) and virulence-promoting pathogen effectors. In grass powdery mildew (PM) fungi, an extreme expansion of a RNase-like effector family, termed RALPH, dominates the effector repertoire, with some members recognized as avirulence (AVR) effectors by cereal NLR receptors. We report the structures of the sequence-unrelated barley PM effectors AVR(A6), AVR(A7), and allelic AVR(A10)/AVR(A22) variants, which are detected by highly sequence-related barley NLRs MLA6, MLA7, MLA10, and MLA22 and of wheat PM AVR(PM2) detected by the unrelated wheat NLR PM2. The AVR effectors adopt a common scaffold, which is shared with the RNase T1/F1 family. We found striking variations in the number, position, and length of individual structural elements between RALPH AVRs, which is associated with a differentiation of RALPH effector subfamilies. We show that all RALPH AVRs tested have lost nuclease and synthetase activities of the RNase T1/F1 family and lack significant binding to RNA, implying that their virulence activities are associated with neo-functionalization events. Structure-guided mutagenesis identified six AVR(A6) residues that are sufficient to turn a sequence-diverged member of the same RALPH subfamily into an effector specifically detected by MLA6. Similar structure-guided information for AVR(A10) and AVR(A22) indicates that MLA receptors detect largely distinct effector surface patches. Thus, coupling of sequence and structural polymorphisms within the RALPH scaffold of PMs facilitated escape from NLR recognition and potential acquisition of diverse virulence functions.

-	~~Authors: Cao~~, Y., Gebauer, J.M., ~~Baumann~~, U., ~~Chai~~, J.J.	+	Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors.,Cao Y, Kummel F, Logemann E, Gebauer JM, Lawson AW, Yu D, Uthoff M, Keller B, Jirschitzka J, Baumann U, Tsuda K, Chai J, Schulze-Lefert P Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2307604120. doi: , 10.1073/pnas.2307604120. Epub 2023 Jul 31. PMID:37523523<ref>PMID:37523523</ref>

-	~~Description: crystal structure~~ of ~~powdery mildews~~ Blumeria graminis f. sp. tritici ~~AVRPM2(1)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Cao, Y~~]]	+	<div class="pdbe-citations 8oxi" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Baumann, U~~]]	+	== References ==
-	[[Category: Chai~~, J.J~~]]	+	<references/>
-	[[Category: Gebauer~~, J.M~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Blumeria graminis f. sp. tritici]]
		+	[[Category: Large Structures]]
		+	[[Category: Baumann U]]
		+	[[Category: Cao Y]]
		+	[[Category: Chai JJ]]
		+	[[Category: Gebauer JM]]

OCA at 09:01, 2 August 2023

OCA — Wed, 02 Aug 2023 09:01:12 GMT

←Older revision		Revision as of 09:01, 2 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8oxi is ON HOLD	+	The entry 8oxi is ON HOLD until 2025-05-02

	Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J.		Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J.

OCA at 19:47, 28 June 2023

OCA — Wed, 28 Jun 2023 19:47:12 GMT

←Older revision		Revision as of 19:47, 28 June 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8oxi is ON HOLD ~~until 2025-05-02~~	+	The entry 8oxi is ON HOLD

	Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J.		Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J.

-	Description: crystal structure of powdery mildews Blumeria graminis f. sp. tritici AVRPM2	+	Description: crystal structure of powdery mildews Blumeria graminis f. sp. tritici AVRPM2(1)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Cao, Y]]		[[Category: Cao, Y]]

OCA at 08:13, 21 June 2023

OCA — Wed, 21 Jun 2023 08:13:07 GMT

←Older revision		Revision as of 08:13, 21 June 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8oxi is ON HOLD	+	The entry 8oxi is ON HOLD until 2025-05-02

	Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J.		Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J.

OCA: Protected "8oxi" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2023 05:16:00 GMT

Protected "8oxi" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:16, 10 May 2023

OCA: New page: '''Unreleased structure''' The entry 8oxi is ON HOLD Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J. Description: crystal structure of powdery mildews Blumeria graminis f. sp....

OCA — Wed, 10 May 2023 05:15:59 GMT

New page: '''Unreleased structure''' The entry 8oxi is ON HOLD Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J. Description: crystal structure of powdery mildews Blumeria graminis f. sp....

New page

'''Unreleased structure'''

The entry 8oxi is ON HOLD

Authors: Cao, Y., Gebauer, J.M., Baumann, U., Chai, J.J.

Description: crystal structure of powdery mildews Blumeria graminis f. sp. tritici AVRPM2
[[Category: Unreleased Structures]]
[[Category: Cao, Y]]
[[Category: Baumann, U]]
[[Category: Chai, J.J]]
[[Category: Gebauer, J.M]]