OCA at 05:20, 15 May 2024

OCA — Wed, 15 May 2024 05:20:18 GMT

←Older revision		Revision as of 05:20, 15 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8oy1 is ~~ON HOLD until Paper Publication~~	+	==Structure of the human Guanine Nucleotide-Binding Protein G(K) Subunit Alpha==
-		+	<StructureSection load='8oy1' size='340' side='right'caption='[[8oy1]], [[Resolution\|resolution]] 3.34Å' scene=''>
-	~~Authors~~: ~~Medrano~~, F.J., ~~Blanco~~, F.J., ~~Ferreras-Gutierrez~~, M.O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8oy1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OY1 FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of the ~~human~~ Guanine ~~Nucleotide~~-~~Binding Protein~~ G(K) ~~Subunit Alpha~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.34Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	[[Category: ~~Ferreras-Gutierrez, M.O~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oy1 OCA], [https://pdbe.org/8oy1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oy1 RCSB], [https://www.ebi.ac.uk/pdbsum/8oy1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oy1 ProSAT]</span></td></tr>
-	[[Category: ~~Medrano, F.J~~]]	+	</table>
-	[[Category: ~~Blanco, F.J~~]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN] Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1) [MIM:[https://omim.org/entry/602483 602483]. ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.<ref>PMID:22560091</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAI3_HUMAN GNAI3_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Blanco FJ]]
		+	[[Category: Ferreras-Gutierrez MO]]
		+	[[Category: Medrano FJ]]

OCA at 08:13, 21 June 2023

OCA — Wed, 21 Jun 2023 08:13:36 GMT

←Older revision		Revision as of 08:13, 21 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8oy1 is ON HOLD	+	The entry 8oy1 is ON HOLD until Paper Publication

	Authors: Medrano, F.J., Blanco, F.J., Ferreras-Gutierrez, M.O.		Authors: Medrano, F.J., Blanco, F.J., Ferreras-Gutierrez, M.O.

OCA: Protected "8oy1" [edit=sysop:move=sysop]

OCA — Wed, 10 May 2023 05:17:16 GMT

Protected "8oy1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:17, 10 May 2023

OCA: New page: '''Unreleased structure''' The entry 8oy1 is ON HOLD Authors: Medrano, F.J., Blanco, F.J., Ferreras-Gutierrez, M.O. Description: Structure of the human Guanine Nucleotide-Binding Prote...

OCA — Wed, 10 May 2023 05:17:15 GMT

New page: '''Unreleased structure''' The entry 8oy1 is ON HOLD Authors: Medrano, F.J., Blanco, F.J., Ferreras-Gutierrez, M.O. Description: Structure of the human Guanine Nucleotide-Binding Prote...

New page

'''Unreleased structure'''

The entry 8oy1 is ON HOLD

Authors: Medrano, F.J., Blanco, F.J., Ferreras-Gutierrez, M.O.

Description: Structure of the human Guanine Nucleotide-Binding Protein G(K) Subunit Alpha
[[Category: Unreleased Structures]]
[[Category: Ferreras-Gutierrez, M.O]]
[[Category: Medrano, F.J]]
[[Category: Blanco, F.J]]

8oy1 - Revision history

OCA at 05:20, 15 May 2024

OCA at 08:13, 21 June 2023

OCA: Protected "8oy1" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8oy1 is ON HOLD Authors: Medrano, F.J., Blanco, F.J., Ferreras-Gutierrez, M.O. Description: Structure of the human Guanine Nucleotide-Binding Prote...