8p04 - Revision history

OCA at 11:11, 22 November 2023

OCA — Wed, 22 Nov 2023 11:11:49 GMT

←Older revision		Revision as of 11:11, 22 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8p04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P04 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8p04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P04 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WB8:(4~{Z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{H}-imidazol-5-one'>WB8</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WB8:(4~{Z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{H}-imidazol-5-one'>WB8</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p04 OCA], [https://pdbe.org/8p04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p04 RCSB], [https://www.ebi.ac.uk/pdbsum/8p04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p04 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p04 OCA], [https://pdbe.org/8p04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p04 RCSB], [https://www.ebi.ac.uk/pdbsum/8p04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p04 ProSAT]</span></td></tr>
	</table>		</table>

OCA: Protected "8p04" [edit=sysop:move=sysop]

OCA — Thu, 18 May 2023 07:03:43 GMT

Protected "8p04" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:03, 18 May 2023

OCA: New page: ==Crystal structure of human CLK1 in complex with Leucettinib-92== ...

OCA — Thu, 18 May 2023 07:03:38 GMT

New page: ==Crystal structure of human CLK1 in complex with Leucettinib-92== <StructureSection load='8p04' size='340' side='right'caption='8p04, resolution 2.60Å' scene=''>...

New page

==Crystal structure of human CLK1 in complex with Leucettinib-92==
<StructureSection load='8p04' size='340' side='right'caption='[[8p04]], [[Resolution|resolution]] 2.60Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8p04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P04 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WB8:(4~{Z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{H}-imidazol-5-one'>WB8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p04 OCA], [https://pdbe.org/8p04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p04 RCSB], [https://www.ebi.ac.uk/pdbsum/8p04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p04 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Knapp S]]
[[Category: Kraemer A]]
[[Category: Meijer L]]
[[Category: Schroeder M]]