OCA at 05:47, 5 July 2023

OCA — Wed, 05 Jul 2023 05:47:41 GMT

←Older revision		Revision as of 05:47, 5 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8p34 is ~~ON HOLD until Paper~~ Publication	+	==Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT==
		+	<StructureSection load='8p34' size='340' side='right'caption='[[8p34]], [[Resolution\|resolution]] 2.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8p34]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P34 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.61Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p34 OCA], [https://pdbe.org/8p34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p34 RCSB], [https://www.ebi.ac.uk/pdbsum/8p34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p34 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> Defects in MAPT are a cause of frontotemporal dementia (FTD) [MIM:[https://omim.org/entry/600274 600274]; also called frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND) or historically termed Pick complex. This form of frontotemporal dementia is characterized by presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:9629852</ref> <ref>PMID:9736786</ref> <ref>PMID:9641683</ref> <ref>PMID:9789048</ref> <ref>PMID:9973279</ref> <ref>PMID:10553987</ref> <ref>PMID:10214944</ref> <ref>PMID:10374757</ref> <ref>PMID:10489057</ref> <ref>PMID:10208578</ref> <ref>PMID:11117541</ref> <ref>PMID:10802785</ref> <ref>PMID:11071507</ref> <ref>PMID:11585254</ref> <ref>PMID:11278002</ref> <ref>PMID:12473774</ref> <ref>PMID:11921059</ref> <ref>PMID:11906000</ref> <ref>PMID:11889249</ref> <ref>PMID:12509859</ref> <ref>PMID:16240366</ref> <ref>PMID:15883319</ref> Defects in MAPT are a cause of Pick disease of the brain (PIDB) [MIM:[https://omim.org/entry/172700 172700]. It is a rare form of dementia pathologically defined by severe atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss and personality deterioration.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:10604746</ref> <ref>PMID:11117542</ref> <ref>PMID:11089577</ref> <ref>PMID:11601501</ref> <ref>PMID:11891833</ref> Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> Defects in MAPT are a cause of progressive supranuclear palsy type 1 (PSNP1) [MIM:[https://omim.org/entry/601104 601104]; also abbreviated as PSP and also known as Steele-Richardson-Olszewski syndrome. PSNP1 is characterized by akinetic-rigid syndrome, supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities deterioration. Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases appear to be sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:10534245</ref> <ref>PMID:11220749</ref> <ref>PMID:12325083</ref> <ref>PMID:14991829</ref> <ref>PMID:14991828</ref> <ref>PMID:16157753</ref> Defects in MAPT are a cause of Parkinson-dementia syndrome (PARDE) [MIM:[https://omim.org/entry/260540 260540]. A syndrome characterized by parkinsonism tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<ref>PMID:21985311</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Two siblings with deletion mutation âK281 in MAPT developed frontotemporal dementia. At autopsy, numerous inclusions of hyperphosphorylated 3R Tau were present in neurons and glial cells of neocortex and some subcortical regions, including hippocampus, caudate/putamen and globus pallidus. The inclusions were argyrophilic with Bodian silver, but not with Gallyas-Braak silver. They were not labelled by an antibody specific for tau phosphorylated at S262 and/or S356. The inclusions were stained by luminescent conjugated oligothiophene HS-84, but not by bTVBT4. Electron cryo-microscopy revealed that the core of tau filaments was made of residues K254-F378 of 3R Tau and was indistinguishable from that of Pick's disease. We conclude that MAPT mutation âK281 causes Pick's disease.

-	~~Authors:~~ Schweighauser, M., Garringer~~, H.J.~~, Klingstedt, T., Masuda-Suzukake, M., Murrell, ~~J.R.~~, Vidal, R., Scheres~~, S.H.W.~~, Goedert, M., Ghetti, B., Newell~~, K~~.L.	+	Mutation âK281 in MAPT causes Pick's disease.,Schweighauser M, Garringer HJ, Klingstedt T, Nilsson KPR, Masuda-Suzukake M, Murrell JR, Risacher SL, Vidal R, Scheres SHW, Goedert M, Ghetti B, Newell KL Acta Neuropathol. 2023 Jun 23. doi: 10.1007/s00401-023-02598-6. PMID:37351604<ref>PMID:37351604</ref>

-	~~Description: Tau filaments extracted from human brain with~~ the ~~DeltaK281 mutation in MAPT~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Goedert, M~~]]	+	<div class="pdbe-citations 8p34" style="background-color:#fffaf0;"></div>
-	[[Category: Garringer~~, H.J~~]]	+	== References ==
-	[[Category: ~~Klingstedt, T~~]]	+	<references/>
-	[[Category: ~~Schweighauser,~~ M]]	+	__TOC__
-	[[Category: ~~Murrell, J.R~~]]	+	</StructureSection>
-	[[Category: ~~Ghetti, B~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Masuda-Suzukake, M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Vidal, R~~]]	+	[[Category: Garringer HJ]]
-	[[Category: ~~Newell, K.L~~]]	+	[[Category: Ghetti B]]
-	[[Category: ~~Scheres, S.H.W~~]]	+	[[Category: Goedert M]]
		+	[[Category: Klingstedt T]]
		+	[[Category: Masuda-Suzukake M]]
		+	[[Category: Murrell JR]]
		+	[[Category: Newell KL]]
		+	[[Category: Scheres SHW]]
		+	[[Category: Schweighauser M]]
		+	[[Category: Vidal R]]

OCA at 08:18, 21 June 2023

OCA — Wed, 21 Jun 2023 08:18:03 GMT

←Older revision		Revision as of 08:18, 21 June 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8p34 is ON HOLD	+	The entry 8p34 is ON HOLD until Paper Publication

	Authors: Schweighauser, M., Garringer, H.J., Klingstedt, T., Masuda-Suzukake, M., Murrell, J.R., Vidal, R., Scheres, S.H.W., Goedert, M., Ghetti, B., Newell, K.L.		Authors: Schweighauser, M., Garringer, H.J., Klingstedt, T., Masuda-Suzukake, M., Murrell, J.R., Vidal, R., Scheres, S.H.W., Goedert, M., Ghetti, B., Newell, K.L.

OCA: Protected "8p34" [edit=sysop:move=sysop]

OCA — Thu, 25 May 2023 02:40:00 GMT

Protected "8p34" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:40, 25 May 2023

OCA: New page: '''Unreleased structure''' The entry 8p34 is ON HOLD Authors: Schweighauser, M., Garringer, H.J., Klingstedt, T., Masuda-Suzukake, M., Murrell, J.R., Vidal, R., Scheres, S.H.W., Goedert...

OCA — Thu, 25 May 2023 02:39:57 GMT

New page: '''Unreleased structure''' The entry 8p34 is ON HOLD Authors: Schweighauser, M., Garringer, H.J., Klingstedt, T., Masuda-Suzukake, M., Murrell, J.R., Vidal, R., Scheres, S.H.W., Goedert...

New page

'''Unreleased structure'''

The entry 8p34 is ON HOLD

Authors: Schweighauser, M., Garringer, H.J., Klingstedt, T., Masuda-Suzukake, M., Murrell, J.R., Vidal, R., Scheres, S.H.W., Goedert, M., Ghetti, B., Newell, K.L.

Description: Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT
[[Category: Unreleased Structures]]
[[Category: Goedert, M]]
[[Category: Garringer, H.J]]
[[Category: Klingstedt, T]]
[[Category: Schweighauser, M]]
[[Category: Murrell, J.R]]
[[Category: Ghetti, B]]
[[Category: Masuda-Suzukake, M]]
[[Category: Vidal, R]]
[[Category: Newell, K.L]]
[[Category: Scheres, S.H.W]]

8p34 - Revision history

OCA at 05:47, 5 July 2023

OCA at 08:18, 21 June 2023

OCA: Protected "8p34" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8p34 is ON HOLD Authors: Schweighauser, M., Garringer, H.J., Klingstedt, T., Masuda-Suzukake, M., Murrell, J.R., Vidal, R., Scheres, S.H.W., Goedert...