OCA at 12:06, 6 March 2024

OCA — Wed, 06 Mar 2024 12:06:52 GMT

←Older revision		Revision as of 12:06, 6 March 2024
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-	'''Unreleased structure'''

-	The entry ~~8p41~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of glucocerebrosidase in complex with allosteric activator==
-		+	<StructureSection load='8p41' size='340' side='right'caption='[[8p41]], [[Resolution\|resolution]] 1.83Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8p41]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P41 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WYC:2-[2-[[3,5-bis(trifluoromethyl)phenyl]methylsulfanyl]ethanoylamino]-5-chloranyl-benzoic+acid'>WYC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p41 OCA], [https://pdbe.org/8p41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p41 RCSB], [https://www.ebi.ac.uk/pdbsum/8p41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p41 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GBA1_HUMAN GBA1_HUMAN] NON RARE IN EUROPE: Dementia with Lewy body;Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome;Fetal Gaucher disease;Gaucher disease type 3;Gaucher disease type 1;NON RARE IN EUROPE: Parkinson disease;Hereditary late-onset Parkinson disease;Gaucher disease type 2. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Perinatal lethal Gaucher disease is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.<ref>PMID:10352942</ref> Disease susceptibility may be associated with variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GBA1_HUMAN GBA1_HUMAN] Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose (PubMed:9201993, PubMed:24211208, PubMed:15916907, PubMed:32144204). Plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol (PubMed:24211208, PubMed:26724485, PubMed:32144204). GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine) (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (PubMed:26724485) (Probable). Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol (PubMed:24211208, PubMed:26724485). Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers (PubMed:32144204). Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside (PubMed:33361282).<ref>PMID:15916907</ref> <ref>PMID:19279011</ref> <ref>PMID:24211208</ref> <ref>PMID:26724485</ref> <ref>PMID:27378698</ref> <ref>PMID:32144204</ref> <ref>PMID:33361282</ref> <ref>PMID:9201993</ref> <ref>PMID:32144204</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Schulze M-S]]

OCA at 19:47, 28 June 2023

OCA — Wed, 28 Jun 2023 19:47:32 GMT

←Older revision		Revision as of 19:47, 28 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8p41 is ON HOLD	+	The entry 8p41 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8p41" [edit=sysop:move=sysop]

OCA — Thu, 25 May 2023 02:41:47 GMT

Protected "8p41" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:41, 25 May 2023

OCA: New page: '''Unreleased structure''' The entry 8p41 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 25 May 2023 02:41:46 GMT

New page: '''Unreleased structure''' The entry 8p41 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8p41 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8p41 - Revision history

OCA at 12:06, 6 March 2024

OCA at 19:47, 28 June 2023

OCA: Protected "8p41" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8p41 is ON HOLD Authors: Description: Category: Unreleased Structures