8p83 - Revision history

OCA at 11:14, 2 August 2023

OCA — Wed, 02 Aug 2023 11:14:42 GMT

←Older revision		Revision as of 11:14, 2 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8p83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P83 FirstGlance]. <br>		<table><tr><td colspan='2'>[[8p83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P83 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p83 OCA], [https://pdbe.org/8p83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p83 RCSB], [https://www.ebi.ac.uk/pdbsum/8p83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p83 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.87Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p83 OCA], [https://pdbe.org/8p83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p83 RCSB], [https://www.ebi.ac.uk/pdbsum/8p83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p83 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 08:22, 14 June 2023

OCA — Wed, 14 Jun 2023 08:22:20 GMT

←Older revision		Revision as of 08:22, 14 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8p83 ~~is ON HOLD~~	+	==Cryo-EM structure of full-length human UBR5 (homotetramer)==
-		+	<StructureSection load='8p83' size='340' side='right'caption='[[8p83]], [[Resolution\|resolution]] 3.87Å' scene=''>
-	~~Authors~~: ~~Aguirre~~, J.D., ~~Kater, L~~., ~~Kempf, G~~., ~~Cavadini, S~~., ~~Thoma, N~~.H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8p83]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P83 FirstGlance]. <br>
-	~~Description~~: ~~Cryo~~-~~EM structure~~ of ~~full~~-~~length human UBR5~~ (~~homotetramer~~)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p83 OCA], [https://pdbe.org/8p83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p83 RCSB], [https://www.ebi.ac.uk/pdbsum/8p83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p83 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Cavadini, S~~]]	+	== Function ==
-	[[Category: ~~Kempf, G~~]]	+	[https://www.uniprot.org/uniprot/UBR5_HUMAN UBR5_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.<ref>PMID:21127351</ref> <ref>PMID:21726808</ref> <ref>PMID:22884692</ref>
-	[[Category: ~~Aguirre, J.D~~]]	+	== References ==
-	[[Category: Kater, L]]	+	<references/>
-	[[Category: Thoma~~, N.H~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Aguirre JD]]
		+	[[Category: Cavadini S]]
		+	[[Category: Kater L]]
		+	[[Category: Kempf G]]
		+	[[Category: Thoma NH]]

OCA: Protected "8p83" [edit=sysop:move=sysop]

OCA — Wed, 07 Jun 2023 04:24:02 GMT

Protected "8p83" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:24, 7 June 2023

OCA: New page: '''Unreleased structure''' The entry 8p83 is ON HOLD Authors: Aguirre, J.D., Kater, L., Kempf, G., Cavadini, S., Thoma, N.H. Description: Cryo-EM structure of full-length human UBR5 (h...

OCA — Wed, 07 Jun 2023 04:24:00 GMT

New page: '''Unreleased structure''' The entry 8p83 is ON HOLD Authors: Aguirre, J.D., Kater, L., Kempf, G., Cavadini, S., Thoma, N.H. Description: Cryo-EM structure of full-length human UBR5 (h...

New page

'''Unreleased structure'''

The entry 8p83 is ON HOLD

Authors: Aguirre, J.D., Kater, L., Kempf, G., Cavadini, S., Thoma, N.H.

Description: Cryo-EM structure of full-length human UBR5 (homotetramer)
[[Category: Unreleased Structures]]
[[Category: Cavadini, S]]
[[Category: Kempf, G]]
[[Category: Aguirre, J.D]]
[[Category: Kater, L]]
[[Category: Thoma, N.H]]