8pfk - Revision history

OCA at 08:02, 1 May 2024

OCA — Wed, 01 May 2024 08:02:45 GMT

←Older revision		Revision as of 08:02, 1 May 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pfk OCA], [https://pdbe.org/8pfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pfk RCSB], [https://www.ebi.ac.uk/pdbsum/8pfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pfk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pfk OCA], [https://pdbe.org/8pfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pfk RCSB], [https://www.ebi.ac.uk/pdbsum/8pfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pfk ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	All widely used mRNA vaccines against COVID-19 contain in their sequence 1-methylpseudouridine (m1Psi) instead of uridine. In this publication, we report two high resolution crystal structures (at up to 1.01 and 1.32 A respectively) of one such double-stranded 12-mer RNA sequence crystallized in two crystal forms. The structures are compared with similar structures which do not contain this modification. Additionally, the structure of 1-methyl-pseudouridine itself was determined.
-
-	RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines.,Nievergelt P, Berliat F, McAuley K, Dorgan CR, van Well RM, Thorn A, Spingler B ChemMedChem. 2024 Jan 18:e202300600. doi: 10.1002/cmdc.202300600. PMID:38235959<ref>PMID:38235959</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 8pfk" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:43, 1 February 2024

OCA — Thu, 01 Feb 2024 11:43:30 GMT

←Older revision		Revision as of 11:43, 1 February 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8pfk is ~~ON HOLD until Paper~~ Publication	+	==RNA structure with 1-methylpseudoridine, C2 space group==
		+	<StructureSection load='8pfk' size='340' side='right'caption='[[8pfk]], [[Resolution\|resolution]] 1.32Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8pfk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PFK FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.321Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B8H:[(2~{R},3~{S},4~{R},5~{S})-5-[1-methyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+dihydrogen+phosphate'>B8H</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pfk OCA], [https://pdbe.org/8pfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pfk RCSB], [https://www.ebi.ac.uk/pdbsum/8pfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pfk ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	All widely used mRNA vaccines against COVID-19 contain in their sequence 1-methylpseudouridine (m1Psi) instead of uridine. In this publication, we report two high resolution crystal structures (at up to 1.01 and 1.32 A respectively) of one such double-stranded 12-mer RNA sequence crystallized in two crystal forms. The structures are compared with similar structures which do not contain this modification. Additionally, the structure of 1-methyl-pseudouridine itself was determined.

-	~~Authors~~:	+	RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines.,Nievergelt P, Berliat F, McAuley K, Dorgan CR, van Well RM, Thorn A, Spingler B ChemMedChem. 2024 Jan 18:e202300600. doi: 10.1002/cmdc.202300600. PMID:38235959<ref>PMID:38235959</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8pfk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: McAuley K]]
		+	[[Category: Nievergelt P]]
		+	[[Category: Spingler B]]
		+	[[Category: Thorn A]]

OCA at 06:39, 16 August 2023

OCA — Wed, 16 Aug 2023 06:39:18 GMT

←Older revision		Revision as of 06:39, 16 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8pfk is ON HOLD	+	The entry 8pfk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8pfk" [edit=sysop:move=sysop]

OCA — Wed, 28 Jun 2023 19:49:20 GMT

Protected "8pfk" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:49, 28 June 2023

OCA: New page: '''Unreleased structure''' The entry 8pfk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Jun 2023 19:49:19 GMT

New page: '''Unreleased structure''' The entry 8pfk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8pfk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]