OCA at 05:32, 9 August 2023

OCA — Wed, 09 Aug 2023 05:32:04 GMT

←Older revision		Revision as of 05:32, 9 August 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8ppz is ~~ON HOLD until Paper Publication~~	+	==Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR==
-		+	<StructureSection load='8ppz' size='340' side='right'caption='[[8ppz]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ppz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PPZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0AN:(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one'>0AN</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ppz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ppz OCA], [https://pdbe.org/8ppz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ppz RCSB], [https://www.ebi.ac.uk/pdbsum/8ppz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ppz ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Deutscher RCE]]
		+	[[Category: Hausch F]]
		+	[[Category: Meyners C]]

OCA: Protected "8ppz" [edit=sysop:move=sysop]

OCA — Wed, 19 Jul 2023 04:53:29 GMT

Protected "8ppz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:53, 19 July 2023

OCA: New page: '''Unreleased structure''' The entry 8ppz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Jul 2023 04:53:28 GMT

New page: '''Unreleased structure''' The entry 8ppz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ppz is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8ppz - Revision history

OCA at 05:32, 9 August 2023

OCA: Protected "8ppz" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ppz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures