8pxs - Revision history

OCA at 14:11, 18 October 2023

OCA — Wed, 18 Oct 2023 14:11:42 GMT

←Older revision		Revision as of 14:11, 18 October 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8pxs is ~~ON HOLD~~	+	==Short RNA binding to peptide amyloids==
		+	<StructureSection load='8pxs' size='340' side='right'caption='[[8pxs]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8pxs]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PXS FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pxs OCA], [https://pdbe.org/8pxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pxs RCSB], [https://www.ebi.ac.uk/pdbsum/8pxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pxs ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Interactions between RNA and proteins are the cornerstone of many important biological processes from transcription and translation to gene regulation, yet little is known about the ancient origin of said interactions. We hypothesized that peptide amyloids played a role in the origin of life and that their repetitive structure lends itself to building interfaces with other polymers through avidity. Here, we report that short RNA with a minimum length of three nucleotides binds in a sequence-dependent manner to peptide amyloids. The 3'-5' linked RNA backbone appears to be well-suited to support these interactions, with the phosphodiester backbone and nucleobases both contributing to the affinity. Sequence-specific RNA-peptide interactions of the kind identified here may provide a path to understanding one of the great mysteries rooted in the origin of life: the origin of the genetic code.

-	~~Authors:~~ Rout~~, S.K.~~, Cadalbert, R., Schroder, N., ~~Wiegand, T.~~, Zehnder, J., Gampp, O., Guntert, P~~., Kringler~~, D., Kreutz, C., Knorlein, A., Hall, J., Greenwald, J., Riek, R.	+	An Analysis of Nucleotide-Amyloid Interactions Reveals Selective Binding to Codon-Sized RNA.,Rout SK, Cadalbert R, Schroder N, Wang J, Zehnder J, Gampp O, Wiegand T, Guntert P, Klingler D, Kreutz C, Knorlein A, Hall J, Greenwald J, Riek R J Am Chem Soc. 2023 Oct 11;145(40):21915-21924. doi: 10.1021/jacs.3c06287. Epub , 2023 Oct 2. PMID:37782045<ref>PMID:37782045</ref>

-	~~Description~~: ~~Short RNA binding to peptide amyloids~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Hall, J~~]]	+	<div class="pdbe-citations 8pxs" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Greenwald, J~~]]	+	== References ==
-	[[Category: ~~Knorlein, A~~]]	+	<references/>
-	[[Category: Guntert, P]]	+	__TOC__
-	[[Category: ~~Schroder, N~~]]	+	</StructureSection>
-	[[Category: ~~Rout, S.K~~]]	+	[[Category: Escherichia coli]]
-	[[Category: ~~Gampp, O~~]]	+	[[Category: Large Structures]]
-	[[Category: Kringler, D]]	+	[[Category: Cadalbert R]]
-	[[Category: ~~Kreutz, C~~]]	+	[[Category: Gampp O]]
-	[[Category: ~~Riek, R~~]]	+	[[Category: Greenwald J]]
-	[[Category: ~~Zehnder, J~~]]	+	[[Category: Guntert P]]
-	[[Category: Wiegand, T]]	+	[[Category: Hall J]]
-	[[Category: ~~Cadalbert, R~~]]	+	[[Category: Knorlein A]]
		+	[[Category: Kreutz C]]
		+	[[Category: Kringler D]]
		+	[[Category: Riek R]]
		+	[[Category: Rout SK]]
		+	[[Category: Schroder N]]
		+	[[Category: Wiegand T]]
		+	[[Category: Zehnder J]]

OCA at 04:51, 27 September 2023

OCA — Wed, 27 Sep 2023 04:51:17 GMT

←Older revision		Revision as of 04:51, 27 September 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8pxs is ON HOLD ~~until Paper Publication~~	+	The entry 8pxs is ON HOLD

	Authors: Rout, S.K., Cadalbert, R., Schroder, N., Wiegand, T., Zehnder, J., Gampp, O., Guntert, P., Kringler, D., Kreutz, C., Knorlein, A., Hall, J., Greenwald, J., Riek, R.		Authors: Rout, S.K., Cadalbert, R., Schroder, N., Wiegand, T., Zehnder, J., Gampp, O., Guntert, P., Kringler, D., Kreutz, C., Knorlein, A., Hall, J., Greenwald, J., Riek, R.
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	Description: Short RNA binding to peptide amyloids		Description: Short RNA binding to peptide amyloids
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Kreutz, C]]
	[[Category: Hall, J]]		[[Category: Hall, J]]
	[[Category: Greenwald, J]]		[[Category: Greenwald, J]]
-	[[Category: Riek, R]]
	[[Category: Knorlein, A]]		[[Category: Knorlein, A]]
	[[Category: Guntert, P]]		[[Category: Guntert, P]]
-	[[Category: Zehnder, J]]
-	[[Category: Wiegand, T]]
	[[Category: Schroder, N]]		[[Category: Schroder, N]]
	[[Category: Rout, S.K]]		[[Category: Rout, S.K]]
	[[Category: Gampp, O]]		[[Category: Gampp, O]]
-	[[Category: Cadalbert, R]]
	[[Category: Kringler, D]]		[[Category: Kringler, D]]
		+	[[Category: Kreutz, C]]
		+	[[Category: Riek, R]]
		+	[[Category: Zehnder, J]]
		+	[[Category: Wiegand, T]]
		+	[[Category: Cadalbert, R]]

OCA at 07:21, 30 August 2023

OCA — Wed, 30 Aug 2023 07:21:02 GMT

←Older revision		Revision as of 07:21, 30 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8pxs is ON HOLD	+	The entry 8pxs is ON HOLD until Paper Publication

	Authors: Rout, S.K., Cadalbert, R., Schroder, N., Wiegand, T., Zehnder, J., Gampp, O., Guntert, P., Kringler, D., Kreutz, C., Knorlein, A., Hall, J., Greenwald, J., Riek, R.		Authors: Rout, S.K., Cadalbert, R., Schroder, N., Wiegand, T., Zehnder, J., Gampp, O., Guntert, P., Kringler, D., Kreutz, C., Knorlein, A., Hall, J., Greenwald, J., Riek, R.

OCA: Protected "8pxs" [edit=sysop:move=sysop]

OCA — Wed, 02 Aug 2023 09:11:41 GMT

Protected "8pxs" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:11, 2 August 2023

OCA: New page: '''Unreleased structure''' The entry 8pxs is ON HOLD Authors: Rout, S.K., Cadalbert, R., Schroder, N., Wiegand, T., Zehnder, J., Gampp, O., Guntert, P., Kringler, D., Kreutz, C., Knorle...

OCA — Wed, 02 Aug 2023 09:11:38 GMT

New page: '''Unreleased structure''' The entry 8pxs is ON HOLD Authors: Rout, S.K., Cadalbert, R., Schroder, N., Wiegand, T., Zehnder, J., Gampp, O., Guntert, P., Kringler, D., Kreutz, C., Knorle...

New page

'''Unreleased structure'''

The entry 8pxs is ON HOLD

Authors: Rout, S.K., Cadalbert, R., Schroder, N., Wiegand, T., Zehnder, J., Gampp, O., Guntert, P., Kringler, D., Kreutz, C., Knorlein, A., Hall, J., Greenwald, J., Riek, R.

Description: Short RNA binding to peptide amyloids
[[Category: Unreleased Structures]]
[[Category: Kreutz, C]]
[[Category: Hall, J]]
[[Category: Greenwald, J]]
[[Category: Riek, R]]
[[Category: Knorlein, A]]
[[Category: Guntert, P]]
[[Category: Zehnder, J]]
[[Category: Wiegand, T]]
[[Category: Schroder, N]]
[[Category: Rout, S.K]]
[[Category: Gampp, O]]
[[Category: Cadalbert, R]]
[[Category: Kringler, D]]