OCA at 14:48, 20 September 2023

OCA — Wed, 20 Sep 2023 14:48:17 GMT

←Older revision		Revision as of 14:48, 20 September 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8pyn is ~~ON HOLD~~	+	==Human IGF1R with inhibitor 56==
-		+	<StructureSection load='8pyn' size='340' side='right'caption='[[8pyn]], [[Resolution\|resolution]] 1.71Å' scene=''>
-	~~Authors~~: ~~Dreyer~~, M.K., ~~Wang~~, J., ~~Elkins~~, J.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8pyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PYN FirstGlance]. <br>
-	~~Description~~: ~~Human~~ IGF1R with ~~inhibitor 56~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.71Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=ICV:5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione'>ICV</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Elkins, J.M~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pyn OCA], [https://pdbe.org/8pyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pyn RCSB], [https://www.ebi.ac.uk/pdbsum/8pyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pyn ProSAT]</span></td></tr>
-	[[Category: Dreyer~~, M.K~~]]	+	</table>
-	[[Category: Wang, J]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/IGF1R_HUMAN IGF1R_HUMAN] Defects in IGF1R are a cause of insulin-like growth factor 1 resistance (IGF1RES) [MIM:[https://omim.org/entry/270450 270450]. It is a disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.<ref>PMID:14657428</ref> <ref>PMID:15928254</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGF1R_HUMAN IGF1R_HUMAN] Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.<ref>PMID:8257688</ref> <ref>PMID:1846292</ref> <ref>PMID:8452530</ref> <ref>PMID:7679099</ref> <ref>PMID:10579905</ref> <ref>PMID:10747872</ref> <ref>PMID:12138094</ref> <ref>PMID:12556535</ref> <ref>PMID:16831875</ref> When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.<ref>PMID:8257688</ref> <ref>PMID:1846292</ref> <ref>PMID:8452530</ref> <ref>PMID:7679099</ref> <ref>PMID:10579905</ref> <ref>PMID:10747872</ref> <ref>PMID:12138094</ref> <ref>PMID:12556535</ref> <ref>PMID:16831875</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Dreyer MK]]
		+	[[Category: Elkins JM]]
		+	[[Category: Wang J]]

OCA: Protected "8pyn" [edit=sysop:move=sysop]

OCA — Wed, 02 Aug 2023 09:14:09 GMT

Protected "8pyn" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:14, 2 August 2023

OCA: New page: '''Unreleased structure''' The entry 8pyn is ON HOLD Authors: Dreyer, M.K., Wang, J., Elkins, J.M. Description: Human IGF1R with inhibitor 56 Category: Unreleased Structures [[Cate...

OCA — Wed, 02 Aug 2023 09:14:08 GMT

New page: '''Unreleased structure''' The entry 8pyn is ON HOLD Authors: Dreyer, M.K., Wang, J., Elkins, J.M. Description: Human IGF1R with inhibitor 56 Category: Unreleased Structures [[Cate...

New page

'''Unreleased structure'''

The entry 8pyn is ON HOLD

Authors: Dreyer, M.K., Wang, J., Elkins, J.M.

Description: Human IGF1R with inhibitor 56
[[Category: Unreleased Structures]]
[[Category: Elkins, J.M]]
[[Category: Dreyer, M.K]]
[[Category: Wang, J]]

8pyn - Revision history

OCA at 14:48, 20 September 2023

OCA: Protected "8pyn" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8pyn is ON HOLD Authors: Dreyer, M.K., Wang, J., Elkins, J.M. Description: Human IGF1R with inhibitor 56 Category: Unreleased Structures [[Cate...