OCA at 13:17, 13 March 2024

OCA — Wed, 13 Mar 2024 13:17:10 GMT

←Older revision		Revision as of 13:17, 13 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8qf4 is ~~ON HOLD until Paper Publication~~	+	==Complex between N-lobe of Arc and nanobody H11==
-		+	<StructureSection load='8qf4' size='340' side='right'caption='[[8qf4]], [[Resolution\|resolution]] 1.02Å' scene=''>
-	~~Authors~~: ~~Godoy Munoz~~, J.M., ~~Kursula~~, P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8qf4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QF4 FirstGlance]. <br>
-	~~Description~~: ~~Complex between N~~-~~lobe~~ of ~~Arc~~ and ~~nanobody H11~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.02Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Kursula, P~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qf4 OCA], [https://pdbe.org/8qf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qf4 RCSB], [https://www.ebi.ac.uk/pdbsum/8qf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qf4 ProSAT]</span></td></tr>
-	[[Category: Godoy Munoz~~, J.M~~]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ARC_HUMAN ARC_HUMAN] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).[UniProtKB:Q63053][UniProtKB:Q9WV31]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Vicugna pacos]]
		+	[[Category: Godoy Munoz JM]]
		+	[[Category: Kursula P]]

OCA at 10:49, 4 October 2023

OCA — Wed, 04 Oct 2023 10:49:42 GMT

←Older revision		Revision as of 10:49, 4 October 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qf4 is ON HOLD	+	The entry 8qf4 is ON HOLD until Paper Publication

	Authors: Godoy Munoz, J.M., Kursula, P.		Authors: Godoy Munoz, J.M., Kursula, P.

OCA: Protected "8qf4" [edit=sysop:move=sysop]

OCA — Wed, 20 Sep 2023 12:10:11 GMT

Protected "8qf4" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:10, 20 September 2023

OCA: New page: '''Unreleased structure''' The entry 8qf4 is ON HOLD Authors: Godoy Munoz, J.M., Kursula, P. Description: Complex between N-lobe of Arc and nanobody H11 [[Category: Unreleased Structur...

OCA — Wed, 20 Sep 2023 12:10:07 GMT

New page: '''Unreleased structure''' The entry 8qf4 is ON HOLD Authors: Godoy Munoz, J.M., Kursula, P. Description: Complex between N-lobe of Arc and nanobody H11 [[Category: Unreleased Structur...

New page

'''Unreleased structure'''

The entry 8qf4 is ON HOLD

Authors: Godoy Munoz, J.M., Kursula, P.

Description: Complex between N-lobe of Arc and nanobody H11
[[Category: Unreleased Structures]]
[[Category: Kursula, P]]
[[Category: Godoy Munoz, J.M]]

8qf4 - Revision history

OCA at 13:17, 13 March 2024

OCA at 10:49, 4 October 2023

OCA: Protected "8qf4" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8qf4 is ON HOLD Authors: Godoy Munoz, J.M., Kursula, P. Description: Complex between N-lobe of Arc and nanobody H11 [[Category: Unreleased Structur...