OCA at 08:33, 9 May 2024

OCA — Thu, 09 May 2024 08:33:33 GMT

←Older revision		Revision as of 08:33, 9 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8qqm is ~~ON HOLD until Paper~~ Publication	+	==nicotinic acetylcholine receptor in intact synaptic membrane==
		+	<StructureSection load='8qqm' size='340' side='right'caption='[[8qqm]], [[Resolution\|resolution]] 4.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8qqm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QQM FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qqm OCA], [https://pdbe.org/8qqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qqm RCSB], [https://www.ebi.ac.uk/pdbsum/8qqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qqm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ACHA_TETCF ACHA_TETCF] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The muscle-type nicotinic acetylcholine receptor is a transmitter-gated ion channel residing in the plasma membrane of electrocytes and striated muscle cells. It is present predominantly at synaptic junctions, where it effects rapid depolarization of the postsynaptic membrane in response to acetylcholine released into the synaptic cleft. Previously, cryo-EM of intact membrane from Torpedo revealed that the lipid bilayer surrounding the junctional receptor has a uniquely asymmetric and ordered structure, due to a high concentration of cholesterol. It is now shown that this special lipid environment influences the transmembrane (TM) folding of the protein. All five submembrane MX helices of the membrane-intact junctional receptor align parallel to the surface of the cholesterol-ordered lipids in the inner leaflet of the bilayer; also, the TM helices in the outer leaflet are splayed apart. However in the structure obtained from the same protein after extraction and incorporation in nanodiscs, the MX helices do not align to a planar surface, and the TM helices arrange compactly in the outer leaflet. Realignment of the MX helices of the nanodisc-solved structure to a planar surface converts their adjoining TM helices into an obligatory splayed configuration, characteristic of the junctional receptor. Thus, the form of the receptor sustained by the special lipid environment of the synaptic junction is the one that mediates fast synaptic transmission; whereas, the nanodisc-embedded protein may be like the extrajunctional form, existing in a disordered lipid environment.

-	~~Authors~~:	+	Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor.,Unwin N Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2319913121. doi: , 10.1073/pnas.2319913121. Epub 2024 Apr 29. PMID:38683987<ref>PMID:38683987</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8qqm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Tetronarce californica]]
		+	[[Category: Unwin N]]

OCA at 09:01, 27 March 2024

OCA — Wed, 27 Mar 2024 09:01:02 GMT

←Older revision		Revision as of 09:01, 27 March 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qqm is ON HOLD	+	The entry 8qqm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8qqm" [edit=sysop:move=sysop]

OCA — Wed, 11 Oct 2023 04:43:22 GMT

Protected "8qqm" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:43, 11 October 2023

OCA: New page: '''Unreleased structure''' The entry 8qqm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Oct 2023 04:43:21 GMT

New page: '''Unreleased structure''' The entry 8qqm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8qqm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8qqm - Revision history

OCA at 08:33, 9 May 2024

OCA at 09:01, 27 March 2024

OCA: Protected "8qqm" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8qqm is ON HOLD Authors: Description: Category: Unreleased Structures