8qrg - Revision history

OCA at 08:33, 9 May 2024

OCA — Thu, 09 May 2024 08:33:38 GMT

←Older revision		Revision as of 08:33, 9 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8qrg is ~~ON HOLD until Paper Publication~~	+	==SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1==
-		+	<StructureSection load='8qrg' size='340' side='right'caption='[[8qrg]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~: ~~Zhou~~, D., ~~Ren~~, J., ~~Stuart~~, D.I.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8qrg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QRG FirstGlance]. <br>
-	~~Description~~: ~~SARS~~-~~CoV~~-~~2 delta RBD complexed with XBB~~-~~2 Fab~~ and ~~NbC1~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: Ren, J]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qrg OCA], [https://pdbe.org/8qrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qrg RCSB], [https://www.ebi.ac.uk/pdbsum/8qrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qrg ProSAT]</span></td></tr>
-	[[Category: Stuart~~, D.I~~]]	+	</table>
-	[[Category: Zhou, D]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Lama glama]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Ren J]]
		+	[[Category: Stuart DI]]
		+	[[Category: Zhou D]]

OCA at 06:21, 29 November 2023

OCA — Wed, 29 Nov 2023 06:21:33 GMT

←Older revision		Revision as of 06:21, 29 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qrg is ON HOLD	+	The entry 8qrg is ON HOLD until Paper Publication

	Authors: Zhou, D., Ren, J., Stuart, D.I.		Authors: Zhou, D., Ren, J., Stuart, D.I.

OCA at 05:49, 22 November 2023

OCA — Wed, 22 Nov 2023 05:49:54 GMT

←Older revision		Revision as of 05:49, 22 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qrg is ON HOLD ~~until Paper Publication~~	+	The entry 8qrg is ON HOLD

	Authors: Zhou, D., Ren, J., Stuart, D.I.		Authors: Zhou, D., Ren, J., Stuart, D.I.

OCA at 05:17, 15 November 2023

OCA — Wed, 15 Nov 2023 05:17:47 GMT

←Older revision		Revision as of 05:17, 15 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qrg is ON HOLD	+	The entry 8qrg is ON HOLD until Paper Publication

	Authors: Zhou, D., Ren, J., Stuart, D.I.		Authors: Zhou, D., Ren, J., Stuart, D.I.

OCA: Protected "8qrg" [edit=sysop:move=sysop]

OCA — Wed, 18 Oct 2023 12:12:08 GMT

Protected "8qrg" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:12, 18 October 2023

OCA: New page: '''Unreleased structure''' The entry 8qrg is ON HOLD Authors: Zhou, D., Ren, J., Stuart, D.I. Description: SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1 [[Category: Unreleased...

OCA — Wed, 18 Oct 2023 12:12:07 GMT

New page: '''Unreleased structure''' The entry 8qrg is ON HOLD Authors: Zhou, D., Ren, J., Stuart, D.I. Description: SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 8qrg is ON HOLD

Authors: Zhou, D., Ren, J., Stuart, D.I.

Description: SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1
[[Category: Unreleased Structures]]
[[Category: Ren, J]]
[[Category: Stuart, D.I]]
[[Category: Zhou, D]]