OCA at 05:22, 15 May 2024

OCA — Wed, 15 May 2024 05:22:10 GMT

←Older revision		Revision as of 05:22, 15 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8qxn is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed==
-		+	<StructureSection load='8qxn' size='340' side='right'caption='[[8qxn]], [[Resolution\|resolution]] 2.98Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8qxn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QXN FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.98Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCP:2-DEOXYCYTIDINE-5-TRIPHOSPHATE'>DCP</scene>, <scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qxn OCA], [https://pdbe.org/8qxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qxn RCSB], [https://www.ebi.ac.uk/pdbsum/8qxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qxn ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN] Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) [MIM:[https://omim.org/entry/612952 612952]. A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.<ref>PMID:19525956</ref> <ref>PMID:20842748</ref> Defects in SAMHD1 are the cause of chilblain lupus type 2 (CHBL2) [MIM:[https://omim.org/entry/614415 614415]. A rare cutaneous form of lupus erythematosus. Affected individuals present with painful bluish-red papular or nodular lesions of the skin in acral locations precipitated by cold and wet exposure at temperatures less than 10 degrees centigrade.<ref>PMID:21204240</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SAMH1_HUMAN SAMH1_HUMAN] Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling.<ref>PMID:18546154</ref> <ref>PMID:19525956</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Acton OJ]]
		+	[[Category: Rosenthal PB]]
		+	[[Category: Sheppard D]]
		+	[[Category: Taylor IA]]

OCA at 07:05, 20 March 2024

OCA — Wed, 20 Mar 2024 07:05:53 GMT

←Older revision		Revision as of 07:05, 20 March 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qxn is ON HOLD	+	The entry 8qxn is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 07:59, 1 March 2024

OCA — Fri, 01 Mar 2024 07:59:33 GMT

←Older revision		Revision as of 07:59, 1 March 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qxn is ON HOLD ~~until Paper Publication~~	+	The entry 8qxn is ON HOLD

	Authors:		Authors:

OCA at 06:31, 29 November 2023

OCA — Wed, 29 Nov 2023 06:31:44 GMT

←Older revision		Revision as of 06:31, 29 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qxn is ON HOLD	+	The entry 8qxn is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8qxn" [edit=sysop:move=sysop]

OCA — Wed, 01 Nov 2023 10:40:06 GMT

Protected "8qxn" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:40, 1 November 2023

OCA: New page: '''Unreleased structure''' The entry 8qxn is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Nov 2023 10:40:03 GMT

New page: '''Unreleased structure''' The entry 8qxn is ON HOLD Authors: Description: Category: Unreleased Structures

New page