OCA at 05:50, 3 April 2024

OCA — Wed, 03 Apr 2024 05:50:01 GMT

←Older revision		Revision as of 05:50, 3 April 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8qzf is ~~ON HOLD until Paper Publication~~	+	==Heme-domain BM3 mutant T268E==
-		+	<StructureSection load='8qzf' size='340' side='right'caption='[[8qzf]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8qzf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QZF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qzf OCA], [https://pdbe.org/8qzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qzf RCSB], [https://www.ebi.ac.uk/pdbsum/8qzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qzf ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Priestia megaterium]]
		+	[[Category: Aschenbrenner JC]]
		+	[[Category: Ebrecht AC]]
		+	[[Category: Opperman DJ]]

OCA at 06:53, 6 December 2023

OCA — Wed, 06 Dec 2023 06:53:58 GMT

←Older revision		Revision as of 06:53, 6 December 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8qzf is ON HOLD	+	The entry 8qzf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8qzf" [edit=sysop:move=sysop]

OCA — Wed, 08 Nov 2023 08:48:06 GMT

Protected "8qzf" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:48, 8 November 2023

OCA: New page: '''Unreleased structure''' The entry 8qzf is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Nov 2023 08:48:04 GMT

New page: '''Unreleased structure''' The entry 8qzf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8qzf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8qzf - Revision history

OCA at 05:50, 3 April 2024

OCA at 06:53, 6 December 2023

OCA: Protected "8qzf" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8qzf is ON HOLD Authors: Description: Category: Unreleased Structures