8r1l - Revision history

OCA at 19:56, 29 May 2024

OCA — Wed, 29 May 2024 19:56:31 GMT

←Older revision		Revision as of 19:56, 29 May 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/AN32B_HUMAN AN32B_HUMAN] Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.<ref>PMID:20538007</ref>		[https://www.uniprot.org/uniprot/AN32B_HUMAN AN32B_HUMAN] Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.<ref>PMID:20538007</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian cells is hindered by species-specific variation in acidic nuclear phosphoprotein 32 (ANP32) proteins, which are essential for viral RNA genome replication. Adaptive mutations enable the IAV RNA polymerase (FluPolA) to surmount this barrier. Here, we present cryo-electron microscopy structures of monomeric and dimeric avian H5N1 FluPolA with human ANP32B. ANP32B interacts with the PA subunit of FluPolA in the monomeric form, at the site used for its docking onto the C-terminal domain of host RNA polymerase II during viral transcription. ANP32B acts as a chaperone, guiding FluPolA towards a ribonucleoprotein-associated FluPolA to form an asymmetric dimer-the replication platform for the viral genome. These findings offer insights into the molecular mechanisms governing IAV genome replication, while enhancing our understanding of the molecular processes underpinning mammalian adaptations in avian-origin FluPolA.
		+
		+	Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.,Staller E, Carrique L, Swann OC, Fan H, Keown JR, Sheppard CM, Barclay WS, Grimes JM, Fodor E Nat Commun. 2024 May 15;15(1):4123. doi: 10.1038/s41467-024-48470-3. PMID:38750014<ref>PMID:38750014</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8r1l" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:33, 9 May 2024

OCA — Thu, 09 May 2024 08:33:47 GMT

←Older revision		Revision as of 08:33, 9 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8r1l is ~~ON HOLD until Paper Publication~~	+	==Structure of avian H5N1 influenza A polymerase in complex with human ANP32B.==
-		+	<StructureSection load='8r1l' size='340' side='right'caption='[[8r1l]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8r1l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R1L FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r1l OCA], [https://pdbe.org/8r1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r1l RCSB], [https://www.ebi.ac.uk/pdbsum/8r1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r1l ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AN32B_HUMAN AN32B_HUMAN] Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.<ref>PMID:20538007</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Influenza A virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Carrique L]]
		+	[[Category: Fan H]]
		+	[[Category: Fodor E]]
		+	[[Category: Grimes JM]]
		+	[[Category: Keown JR]]
		+	[[Category: Staller E]]

OCA at 09:51, 13 December 2023

OCA — Wed, 13 Dec 2023 09:51:34 GMT

←Older revision		Revision as of 09:51, 13 December 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8r1l is ON HOLD	+	The entry 8r1l is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8r1l" [edit=sysop:move=sysop]

OCA — Wed, 08 Nov 2023 08:54:44 GMT

Protected "8r1l" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:54, 8 November 2023

OCA: New page: '''Unreleased structure''' The entry 8r1l is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Nov 2023 08:54:43 GMT

New page: '''Unreleased structure''' The entry 8r1l is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8r1l is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]