OCA at 08:20, 20 March 2024

OCA — Wed, 20 Mar 2024 08:20:16 GMT

←Older revision		Revision as of 08:20, 20 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8r1p is ~~ON HOLD until Paper Publication~~	+	==Pim1 in complex with 6-bromobenzo[d]oxazol-2-amine and Pimtide==
-		+	<StructureSection load='8r1p' size='340' side='right'caption='[[8r1p]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~Authors~~: ~~Hochban~~, P.M.M., ~~Heine~~, A., ~~Diederich~~, W.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8r1p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R1P FirstGlance]. <br>
-	~~Description~~: ~~Pim1 in complex~~ with 6-~~bromobenzo[d]oxazol~~-2-~~amine~~ and ~~Pimtide~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=XIP:4-(4-aminostyryl)benzoic+acid'>XIP</scene></td></tr>
-	[[Category: ~~Heine, A~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r1p OCA], [https://pdbe.org/8r1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r1p RCSB], [https://www.ebi.ac.uk/pdbsum/8r1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r1p ProSAT]</span></td></tr>
-	[[Category: ~~Hochban, P.M.M~~]]	+	</table>
-	[[Category: ~~Diederich, W.E~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/PIM1_HUMAN PIM1_HUMAN] Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.<ref>PMID:1825810</ref> <ref>PMID:10664448</ref> <ref>PMID:12431783</ref> <ref>PMID:15528381</ref> <ref>PMID:16356754</ref> <ref>PMID:18593906</ref> <ref>PMID:19749799</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Diederich WE]]
		+	[[Category: Heine A]]
		+	[[Category: Hochban PMM]]

OCA at 06:43, 29 November 2023

OCA — Wed, 29 Nov 2023 06:43:36 GMT

←Older revision		Revision as of 06:43, 29 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8r1p is ON HOLD	+	The entry 8r1p is ON HOLD until Paper Publication

	Authors: Hochban, P.M.M., Heine, A., Diederich, W.E.		Authors: Hochban, P.M.M., Heine, A., Diederich, W.E.

OCA at 05:53, 22 November 2023

OCA — Wed, 22 Nov 2023 05:53:05 GMT

←Older revision		Revision as of 05:53, 22 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8r1p is ON HOLD ~~until Paper Publication~~	+	The entry 8r1p is ON HOLD

	Authors: Hochban, P.M.M., Heine, A., Diederich, W.E.		Authors: Hochban, P.M.M., Heine, A., Diederich, W.E.

OCA at 05:23, 15 November 2023

OCA — Wed, 15 Nov 2023 05:23:18 GMT

←Older revision		Revision as of 05:23, 15 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8r1p is ON HOLD	+	The entry 8r1p is ON HOLD until Paper Publication

	Authors: Hochban, P.M.M., Heine, A., Diederich, W.E.		Authors: Hochban, P.M.M., Heine, A., Diederich, W.E.

OCA: Protected "8r1p" [edit=sysop:move=sysop]

OCA — Wed, 08 Nov 2023 08:55:00 GMT

Protected "8r1p" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:55, 8 November 2023

OCA: New page: '''Unreleased structure''' The entry 8r1p is ON HOLD Authors: Hochban, P.M.M., Heine, A., Diederich, W.E. Description: Pim1 in complex with 6-bromobenzo[d]oxazol-2-amine and Pimtide [[...

OCA — Wed, 08 Nov 2023 08:54:59 GMT

New page: '''Unreleased structure''' The entry 8r1p is ON HOLD Authors: Hochban, P.M.M., Heine, A., Diederich, W.E. Description: Pim1 in complex with 6-bromobenzo[d]oxazol-2-amine and Pimtide [[...

New page