OCA at 18:04, 29 May 2024

OCA — Wed, 29 May 2024 18:04:48 GMT

←Older revision		Revision as of 18:04, 29 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8r9o is ~~ON HOLD until Paper Publication~~	+	==A soakable crystal form of human CDK7 in complex with AMP-PNP==
-		+	<StructureSection load='8r9o' size='340' side='right'caption='[[8r9o]], [[Resolution\|resolution]] 2.22Å' scene=''>
-	~~Authors~~: ~~Mukherjee~~, M., ~~Cleasby~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8r9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R9O FirstGlance]. <br>
-	~~Description~~: ~~A soakable crystal form~~ of ~~human~~ CDK7 in complex with ~~AMP~~-~~PNP~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YN3:~{N}-[(1~{S})-2-(dimethylamino)-1-phenyl-ethyl]-6,6-dimethyl-3-[[4-(propanoylamino)phenyl]carbonylamino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide'>YN3</scene></td></tr>
-	[[Category: Cleasby, A]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r9o OCA], [https://pdbe.org/8r9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r9o RCSB], [https://www.ebi.ac.uk/pdbsum/8r9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r9o ProSAT]</span></td></tr>
-	[[Category: Mukherjee, M]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CDK7_HUMAN CDK7_HUMAN] Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.<ref>PMID:9372954</ref> <ref>PMID:9840937</ref> <ref>PMID:10024882</ref> <ref>PMID:11113184</ref> <ref>PMID:16327805</ref> <ref>PMID:17386261</ref> <ref>PMID:17373709</ref> <ref>PMID:17901130</ref> <ref>PMID:19450536</ref> <ref>PMID:19015234</ref> <ref>PMID:19667075</ref> <ref>PMID:19136461</ref> <ref>PMID:19071173</ref> <ref>PMID:20360007</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Cleasby A]]
		+	[[Category: Mukherjee M]]

OCA at 09:15, 10 January 2024

OCA — Wed, 10 Jan 2024 09:15:55 GMT

←Older revision		Revision as of 09:15, 10 January 2024
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8r9o is ON HOLD	+	The entry 8r9o is ON HOLD until Paper Publication

	Authors: Mukherjee, M., Cleasby, A.		Authors: Mukherjee, M., Cleasby, A.

OCA: Protected "8r9o" [edit=sysop:move=sysop]

OCA — Wed, 06 Dec 2023 06:59:33 GMT

Protected "8r9o" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:59, 6 December 2023

OCA: New page: '''Unreleased structure''' The entry 8r9o is ON HOLD Authors: Mukherjee, M., Cleasby, A. Description: A soakable crystal form of human CDK7 in complex with AMP-PNP [[Category: Unreleas...

OCA — Wed, 06 Dec 2023 06:59:32 GMT

New page: '''Unreleased structure''' The entry 8r9o is ON HOLD Authors: Mukherjee, M., Cleasby, A. Description: A soakable crystal form of human CDK7 in complex with AMP-PNP [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 8r9o is ON HOLD

Authors: Mukherjee, M., Cleasby, A.

Description: A soakable crystal form of human CDK7 in complex with AMP-PNP
[[Category: Unreleased Structures]]
[[Category: Cleasby, A]]
[[Category: Mukherjee, M]]

8r9o - Revision history

OCA at 18:04, 29 May 2024

OCA at 09:15, 10 January 2024

OCA: Protected "8r9o" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8r9o is ON HOLD Authors: Mukherjee, M., Cleasby, A. Description: A soakable crystal form of human CDK7 in complex with AMP-PNP [[Category: Unreleas...