8rhl - Revision history

OCA at 06:21, 1 May 2024

OCA — Wed, 01 May 2024 06:21:56 GMT

←Older revision		Revision as of 06:21, 1 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8rhl ~~is ON HOLD until Paper Publication~~	+	==Yeast 20S proteasome in complex with a linear biarylether epoxyketone (compound 15a)==
-		+	<StructureSection load='8rhl' size='340' side='right'caption='[[8rhl]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~: ~~Goetz, M~~.G.~~, Godwin, K~~.~~, Price, R~~., ~~Dorn, R~~., ~~Merrill~~-~~Steskal~~, G., ~~Hansen~~, H., ~~Klemmer~~, W., ~~Produturi~~, G., ~~Rocha, M~~., ~~Palmer, M~~., ~~Molacek, L~~., ~~Strater, Z~~., ~~Groll, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8rhl]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RHL FirstGlance]. <br>
-	~~Description~~: ~~Yeast 20S~~ proteasome in complex with ~~a linear biarylether epoxyketone (compound 15a)~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6VO:(3~{R},4~{S})-4-AZANYL-2,6-DIMETHYL-HEPTANE-2,3-DIOL'>6VO</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPN:PARA-NITROPHENYLALANINE'>PPN</scene></td></tr>
-	[[Category: ~~Produturi, G~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rhl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rhl OCA], [https://pdbe.org/8rhl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rhl RCSB], [https://www.ebi.ac.uk/pdbsum/8rhl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rhl ProSAT]</span></td></tr>
-	[[Category: ~~Merrill-Steskal, G~~]]	+	</table>
-	[[Category: ~~Klemmer, W~~]]	+	== Function ==
-	[[Category: ~~Rocha, M~~]]	+	[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
-	[[Category: Groll, M]]	+	__TOC__
-	[[Category: Hansen, H]]	+	</StructureSection>
-	[[Category: ~~Molacek, L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Palmer, M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Goetz, M.G~~]]	+	[[Category: Dorn R]]
-	[[Category: ~~Strater, Z~~]]	+	[[Category: Godwin K]]
-	[[Category: ~~Dorn,~~ R]]	+	[[Category: Goetz MG]]
-	[[Category: ~~Godwin, K~~]]	+	[[Category: Groll M]]
-	[[Category: ~~Price, R~~]]	+	[[Category: Hansen H]]
		+	[[Category: Klemmer W]]
		+	[[Category: Merrill-Steskal G]]
		+	[[Category: Molacek L]]
		+	[[Category: Palmer M]]
		+	[[Category: Price R]]
		+	[[Category: Produturi G]]
		+	[[Category: Rocha M]]
		+	[[Category: Strater Z]]

OCA at 07:44, 21 February 2024

OCA — Wed, 21 Feb 2024 07:44:09 GMT

←Older revision		Revision as of 07:44, 21 February 2024
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8rhl is ON HOLD	+	The entry 8rhl is ON HOLD until Paper Publication

	Authors: Goetz, M.G., Godwin, K., Price, R., Dorn, R., Merrill-Steskal, G., Hansen, H., Klemmer, W., Produturi, G., Rocha, M., Palmer, M., Molacek, L., Strater, Z., Groll, M.		Authors: Goetz, M.G., Godwin, K., Price, R., Dorn, R., Merrill-Steskal, G., Hansen, H., Klemmer, W., Produturi, G., Rocha, M., Palmer, M., Molacek, L., Strater, Z., Groll, M.
Line 7:		Line 7:
	Description: Yeast 20S proteasome in complex with a linear biarylether epoxyketone (compound 15a)		Description: Yeast 20S proteasome in complex with a linear biarylether epoxyketone (compound 15a)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Produturi, G]]
		+	[[Category: Merrill-Steskal, G]]
	[[Category: Klemmer, W]]		[[Category: Klemmer, W]]
	[[Category: Rocha, M]]		[[Category: Rocha, M]]
		+	[[Category: Groll, M]]
	[[Category: Hansen, H]]		[[Category: Hansen, H]]
	[[Category: Molacek, L]]		[[Category: Molacek, L]]
-	[[Category: Dorn, R]]
-	[[Category: Produturi, G]]
-	[[Category: Merrill-Steskal, G]]
-	[[Category: Groll, M]]
	[[Category: Palmer, M]]		[[Category: Palmer, M]]
	[[Category: Goetz, M.G]]		[[Category: Goetz, M.G]]
	[[Category: Strater, Z]]		[[Category: Strater, Z]]
		+	[[Category: Dorn, R]]
	[[Category: Godwin, K]]		[[Category: Godwin, K]]
	[[Category: Price, R]]		[[Category: Price, R]]

OCA: Protected "8rhl" [edit=sysop:move=sysop]

OCA — Wed, 27 Dec 2023 22:07:13 GMT

Protected "8rhl" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:07, 27 December 2023

OCA: New page: '''Unreleased structure''' The entry 8rhl is ON HOLD Authors: Goetz, M.G., Godwin, K., Price, R., Dorn, R., Merrill-Steskal, G., Hansen, H., Klemmer, W., Produturi, G., Rocha, M., Palme...

OCA — Wed, 27 Dec 2023 22:07:12 GMT

New page: '''Unreleased structure''' The entry 8rhl is ON HOLD Authors: Goetz, M.G., Godwin, K., Price, R., Dorn, R., Merrill-Steskal, G., Hansen, H., Klemmer, W., Produturi, G., Rocha, M., Palme...

New page

'''Unreleased structure'''

The entry 8rhl is ON HOLD

Authors: Goetz, M.G., Godwin, K., Price, R., Dorn, R., Merrill-Steskal, G., Hansen, H., Klemmer, W., Produturi, G., Rocha, M., Palmer, M., Molacek, L., Strater, Z., Groll, M.

Description: Yeast 20S proteasome in complex with a linear biarylether epoxyketone (compound 15a)
[[Category: Unreleased Structures]]
[[Category: Klemmer, W]]
[[Category: Rocha, M]]
[[Category: Hansen, H]]
[[Category: Molacek, L]]
[[Category: Dorn, R]]
[[Category: Produturi, G]]
[[Category: Merrill-Steskal, G]]
[[Category: Groll, M]]
[[Category: Palmer, M]]
[[Category: Goetz, M.G]]
[[Category: Strater, Z]]
[[Category: Godwin, K]]
[[Category: Price, R]]