OCA at 07:21, 14 February 2024

OCA — Wed, 14 Feb 2024 07:21:13 GMT

←Older revision		Revision as of 07:21, 14 February 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8rq3 is ~~ON HOLD~~	+	==Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in an autoinhibited state (nucleotide-free)==
-		+	<StructureSection load='8rq3' size='340' side='right'caption='[[8rq3]], [[Resolution\|resolution]] 3.21Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8rq3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQ3 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.21Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rq3 OCA], [https://pdbe.org/8rq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rq3 RCSB], [https://www.ebi.ac.uk/pdbsum/8rq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rq3 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/MRP2_RAT MRP2_RAT] Defects in Abcc2 are a cause of hereditary conjugated hyperbilirubinemia (EHBR).<ref>PMID:8599091</ref> [REFERENCE:3]
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MRP2_RAT MRP2_RAT] ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:8662992, PubMed:10421658, PubMed:10220572, PubMed:11248200). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:10220572, PubMed:8662992). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:11248200). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (By similarity).[UniProtKB:Q92887]<ref>PMID:10220572</ref> <ref>PMID:10421658</ref> <ref>PMID:11248200</ref> <ref>PMID:8662992</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Beis K]]
		+	[[Category: Mazza T]]

OCA: Protected "8rq3" [edit=sysop:move=sysop]

OCA — Wed, 24 Jan 2024 10:15:07 GMT

Protected "8rq3" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:15, 24 January 2024

OCA: New page: '''Unreleased structure''' The entry 8rq3 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 24 Jan 2024 10:15:06 GMT

New page: '''Unreleased structure''' The entry 8rq3 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8rq3 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8rq3 - Revision history

OCA at 07:21, 14 February 2024

OCA: Protected "8rq3" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8rq3 is ON HOLD Authors: Description: Category: Unreleased Structures