OCA at 13:17, 13 March 2024

OCA — Wed, 13 Mar 2024 13:17:52 GMT

←Older revision		Revision as of 13:17, 13 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8sd8 is ~~ON HOLD~~	+	==Carbonic anhydrase II radiation damage RT 91-120==
-		+	<StructureSection load='8sd8' size='340' side='right'caption='[[8sd8]], [[Resolution\|resolution]] 1.79Å' scene=''>
-	~~Authors~~: ~~Combs~~, J.E., ~~Mckenna~~, R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8sd8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SD8 FirstGlance]. <br>
-	~~Description~~: ~~Carbonic~~ anhydrase II ~~radiation damage RT 91~~-~~120~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.789Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Mckenna, R~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sd8 OCA], [https://pdbe.org/8sd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sd8 RCSB], [https://www.ebi.ac.uk/pdbsum/8sd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sd8 ProSAT]</span></td></tr>
-	[[Category: Combs~~, J.E~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Combs JE]]
		+	[[Category: Mckenna R]]

OCA: Protected "8sd8" [edit=sysop:move=sysop]

OCA — Wed, 12 Apr 2023 19:10:44 GMT

Protected "8sd8" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:10, 12 April 2023

OCA: New page: '''Unreleased structure''' The entry 8sd8 is ON HOLD Authors: Combs, J.E., Mckenna, R. Description: Carbonic anhydrase II radiation damage RT 91-120 Category: Unreleased Structures...

OCA — Wed, 12 Apr 2023 19:10:41 GMT

New page: '''Unreleased structure''' The entry 8sd8 is ON HOLD Authors: Combs, J.E., Mckenna, R. Description: Carbonic anhydrase II radiation damage RT 91-120 Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 8sd8 is ON HOLD

Authors: Combs, J.E., Mckenna, R.

Description: Carbonic anhydrase II radiation damage RT 91-120
[[Category: Unreleased Structures]]
[[Category: Mckenna, R]]
[[Category: Combs, J.E]]

8sd8 - Revision history

OCA at 13:17, 13 March 2024

OCA: Protected "8sd8" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8sd8 is ON HOLD Authors: Combs, J.E., Mckenna, R. Description: Carbonic anhydrase II radiation damage RT 91-120 Category: Unreleased Structures...