OCA at 06:16, 19 July 2023

OCA — Wed, 19 Jul 2023 06:16:59 GMT

←Older revision		Revision as of 06:16, 19 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8sg7 is ~~ON HOLD~~	+	==Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2==
-		+	<StructureSection load='8sg7' size='340' side='right'caption='[[8sg7]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~: ~~Hoad~~, M., ~~Forwood~~, J.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8sg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bat_adeno-associated_virus Bat adeno-associated virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SG7 FirstGlance]. <br>
-	~~Description~~: ~~Adeno-Associated Virus Bat origin capsid protein basic regions~~ in complex ~~with~~ importin-alpha 2	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sg7 OCA], [https://pdbe.org/8sg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sg7 RCSB], [https://www.ebi.ac.uk/pdbsum/8sg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sg7 ProSAT]</span></td></tr>
-	[[Category: ~~Hoad, M~~]]	+	</table>
-	[[Category: Forwood~~, J.K~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bat adeno-associated virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Forwood JK]]
		+	[[Category: Hoad M]]

OCA at 15:23, 26 April 2023

OCA — Wed, 26 Apr 2023 15:23:03 GMT

←Older revision		Revision as of 15:23, 26 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8sg7 is ON HOLD ~~until sometime in the future~~	+	The entry 8sg7 is ON HOLD

	Authors: Hoad, M., Forwood, J.K.		Authors: Hoad, M., Forwood, J.K.

OCA: Protected "8sg7" [edit=sysop:move=sysop]

OCA — Wed, 19 Apr 2023 08:20:06 GMT

Protected "8sg7" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:20, 19 April 2023

OCA: New page: '''Unreleased structure''' The entry 8sg7 is ON HOLD until sometime in the future Authors: Hoad, M., Forwood, J.K. Description: Adeno-Associated Virus Bat origin capsid protein basic r...

OCA — Wed, 19 Apr 2023 08:20:05 GMT

New page: '''Unreleased structure''' The entry 8sg7 is ON HOLD until sometime in the future Authors: Hoad, M., Forwood, J.K. Description: Adeno-Associated Virus Bat origin capsid protein basic r...

New page

'''Unreleased structure'''

The entry 8sg7 is ON HOLD until sometime in the future

Authors: Hoad, M., Forwood, J.K.

Description: Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2
[[Category: Unreleased Structures]]
[[Category: Hoad, M]]
[[Category: Forwood, J.K]]

8sg7 - Revision history

OCA at 06:16, 19 July 2023

OCA at 15:23, 26 April 2023

OCA: Protected "8sg7" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8sg7 is ON HOLD until sometime in the future Authors: Hoad, M., Forwood, J.K. Description: Adeno-Associated Virus Bat origin capsid protein basic r...