8shj - Revision history

OCA at 05:48, 5 July 2023

OCA — Wed, 05 Jul 2023 05:48:37 GMT

←Older revision		Revision as of 05:48, 5 July 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8shj ~~is ON HOLD~~	+	==Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279==
-		+	<StructureSection load='8shj' size='340' side='right'caption='[[8shj]], [[Resolution\|resolution]] 2.21Å' scene=''>
-	~~Authors~~: ~~Ahmad, H~~.~~, Zeng, H~~.~~, Dong, A~~.~~, Li, Y~~.~~, Hutchinson, A~~.~~, Seitova, A~~.~~, Xu, J~~.~~, Feng, J~~.W., ~~Brown, P~~.J.~~, Ackloo, S~~., ~~Arrowsmith, C~~.H., ~~Edwards~~, A.M., ~~Halabelian, L~~., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8shj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SHJ FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of the WD-~~repeat domain~~ of ~~human WDR91~~ in ~~complex with MR45279~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.21Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZI8:N-[3-(4-chlorophenyl)oxetan-3-yl]-4-[(3S)-3-hydroxypyrrolidin-1-yl]benzamide'>ZI8</scene></td></tr>
-	[[Category: ~~Hutchinson, A~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8shj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8shj OCA], [https://pdbe.org/8shj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8shj RCSB], [https://www.ebi.ac.uk/pdbsum/8shj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8shj ProSAT]</span></td></tr>
-	[[Category: ~~Edwards, A.M~~]]	+	</table>
-	[[Category: ~~Arrowsmith, C.~~H]]	+	== Function ==
-	[[Category: ~~Xu, J~~]]	+	[https://www.uniprot.org/uniprot/WDR91_HUMAN WDR91_HUMAN] Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).[UniProtKB:Q7TMQ7]<ref>PMID:26783301</ref> <ref>PMID:27126989</ref>
-	[[Category: ~~Seitova, A~~]]	+	== References ==
-	[[Category: Dong, A]]	+	<references/>
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	__TOC__
-	[[Category: ~~Li, Y~~]]	+	</StructureSection>
-	[[Category: Halabelian, L]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Brown, P.J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ackloo, S~~]]	+	[[Category: Ackloo S]]
-	[[Category: ~~Feng, J.W~~]]	+	[[Category: Ahmad H]]
-	[[Category: ~~Zeng, H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: ~~Ahmad,~~ H]]	+	[[Category: Brown PJ]]
		+	[[Category: Dong A]]
		+	[[Category: Edwards AM]]
		+	[[Category: Feng JW]]
		+	[[Category: Halabelian L]]
		+	[[Category: Hutchinson A]]
		+	[[Category: Li Y]]
		+	[[Category: Seitova A]]
		+	[[Category: Xu J]]
		+	[[Category: Zeng H]]

OCA at 04:25, 7 June 2023

OCA — Wed, 07 Jun 2023 04:25:16 GMT

←Older revision		Revision as of 04:25, 7 June 2023
Line 3:		Line 3:
	The entry 8shj is ON HOLD		The entry 8shj is ON HOLD

-	Authors: Ahmad, H., Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Xu, J., Feng, J.W., Brown, P.J., Ackloo, S., Arrowsmith, C.H., Edwards, A.M., Halabelian, L.	+	Authors: Ahmad, H., Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Xu, J., Feng, J.W., Brown, P.J., Ackloo, S., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)

	Description: Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279		Description: Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279
Line 13:		Line 13:
	[[Category: Seitova, A]]		[[Category: Seitova, A]]
	[[Category: Dong, A]]		[[Category: Dong, A]]
		+	[[Category: Structural Genomics Consortium (Sgc)]]
	[[Category: Li, Y]]		[[Category: Li, Y]]
	[[Category: Halabelian, L]]		[[Category: Halabelian, L]]

OCA: Protected "8shj" [edit=sysop:move=sysop]

OCA — Wed, 26 Apr 2023 15:23:29 GMT

Protected "8shj" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:23, 26 April 2023

OCA: New page: '''Unreleased structure''' The entry 8shj is ON HOLD Authors: Ahmad, H., Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Xu, J., Feng, J.W., Brown, P.J., Ackloo, S., Arrowsmith...

OCA — Wed, 26 Apr 2023 15:23:28 GMT

New page: '''Unreleased structure''' The entry 8shj is ON HOLD Authors: Ahmad, H., Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Xu, J., Feng, J.W., Brown, P.J., Ackloo, S., Arrowsmith...

New page

'''Unreleased structure'''

The entry 8shj is ON HOLD

Authors: Ahmad, H., Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Xu, J., Feng, J.W., Brown, P.J., Ackloo, S., Arrowsmith, C.H., Edwards, A.M., Halabelian, L.

Description: Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279
[[Category: Unreleased Structures]]
[[Category: Hutchinson, A]]
[[Category: Edwards, A.M]]
[[Category: Arrowsmith, C.H]]
[[Category: Xu, J]]
[[Category: Seitova, A]]
[[Category: Dong, A]]
[[Category: Li, Y]]
[[Category: Halabelian, L]]
[[Category: Brown, P.J]]
[[Category: Ackloo, S]]
[[Category: Feng, J.W]]
[[Category: Zeng, H]]
[[Category: Ahmad, H]]