OCA at 09:19, 30 August 2023

OCA — Wed, 30 Aug 2023 09:19:59 GMT

←Older revision		Revision as of 09:19, 30 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8skn is ~~ON HOLD until 2025~~-04-20	+	==Crystal structure of compound 3-bound human Dynamin-1-like protein GTPase-BSE fusion==
		+	<StructureSection load='8skn' size='340' side='right'caption='[[8skn]], [[Resolution\|resolution]] 2.41Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8skn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SKN FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.41Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6I9:N-[4-(azetidin-1-yl)-2-(4-methylphenyl)quinolin-6-yl]-2-methylpropanamide'>6I9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8skn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8skn OCA], [https://pdbe.org/8skn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8skn RCSB], [https://www.ebi.ac.uk/pdbsum/8skn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8skn ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D3DUW7_HUMAN D3DUW7_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mitochondrial dysfunction has been attributed to many disease indications, including metabolic, cardiovascular, neoplastic, and neurodegenerative diseases. Dynamin related protein 1 (DRP1) is crucial in regulating mitochondrial fission and maintaining mitochondrial homeostasis. MiD49 is a dynamic peripheral protein receptor on the surface of the mitochondrial membrane that recruits DRP1 protein to induce mitochondrial binary fission. By targeting the protein-protein interaction of DRP1/MiD49, we have discovered a novel and potent allosteric DRP1 inhibitor that inhibits mitochondria fragmentation in vitro. X-ray cocrystal structure revealed that it locked the closed DRP1 conformation by induced dimerization.

-	~~Authors~~:	+	Discovery of Potent Allosteric DRP1 Inhibitors by Disrupting Protein-Protein Interaction with MiD49.,Furuya T, Lin J, Afanaseva A, Molz L, Lagu B, Ma B ACS Med Chem Lett. 2023 Jul 24;14(8):1095-1099. doi: , 10.1021/acsmedchemlett.3c00223. eCollection 2023 Aug 10. PMID:37583827<ref>PMID:37583827</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8skn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Ma B]]

OCA at 05:51, 3 May 2023

OCA — Wed, 03 May 2023 05:51:59 GMT

←Older revision		Revision as of 05:51, 3 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8skn is ON HOLD	+	The entry 8skn is ON HOLD until 2025-04-20

	Authors:		Authors:

OCA: Protected "8skn" [edit=sysop:move=sysop]

OCA — Wed, 26 Apr 2023 15:29:26 GMT

Protected "8skn" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:29, 26 April 2023

OCA: New page: '''Unreleased structure''' The entry 8skn is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Apr 2023 15:29:25 GMT

New page: '''Unreleased structure''' The entry 8skn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8skn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8skn - Revision history

OCA at 09:19, 30 August 2023

OCA at 05:51, 3 May 2023

OCA: Protected "8skn" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8skn is ON HOLD Authors: Description: Category: Unreleased Structures